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A genomic history of Aboriginal Australia.
Malaspinas, Anna-Sapfo; Westaway, Michael C; Muller, Craig; Sousa, Vitor C; Lao, Oscar; Alves, Isabel; Bergström, Anders; Athanasiadis, Georgios; Cheng, Jade Y; Crawford, Jacob E; Heupink, Tim H; Macholdt, Enrico; Peischl, Stephan; Rasmussen, Simon; Schiffels, Stephan; Subramanian, Sankar; Wright, Joanne L; Albrechtsen, Anders; Barbieri, Chiara; Dupanloup, Isabelle; Eriksson, Anders; Margaryan, Ashot; Moltke, Ida; Pugach, Irina; Korneliussen, Thorfinn S; Levkivskyi, Ivan P; Moreno-Mayar, J Víctor; Ni, Shengyu; Racimo, Fernando; Sikora, Martin; Xue, Yali; Aghakhanian, Farhang A; Brucato, Nicolas; Brunak, Søren; Campos, Paula F; Clark, Warren; Ellingvåg, Sturla; Fourmile, Gudjugudju; Gerbault, Pascale; Injie, Darren; Koki, George; Leavesley, Matthew; Logan, Betty; Lynch, Aubrey; Matisoo-Smith, Elizabeth A; McAllister, Peter J; Mentzer, Alexander J; Metspalu, Mait; Migliano, Andrea B; Murgha, Les.
Affiliation
  • Malaspinas AS; Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5-7, 1350 Copenhagen, Denmark.
  • Westaway MC; Institute of Ecology and Evolution, University of Bern, Baltzerstrasse 6, 3012 Bern, Switzerland.
  • Muller C; Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland.
  • Sousa VC; Research Centre for Human Evolution, Environmental Futures Research Institute, Griffith University, Nathan, Queensland 4111, Australia.
  • Lao O; Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5-7, 1350 Copenhagen, Denmark.
  • Alves I; Institute of Ecology and Evolution, University of Bern, Baltzerstrasse 6, 3012 Bern, Switzerland.
  • Bergström A; Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland.
  • Athanasiadis G; CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Baldiri i Reixac 4, 08028 Barcelona, Spain.
  • Cheng JY; Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain.
  • Crawford JE; Institute of Ecology and Evolution, University of Bern, Baltzerstrasse 6, 3012 Bern, Switzerland.
  • Heupink TH; Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland.
  • Macholdt E; Population and Conservation Genetics Group, Instituto Gulbenkian de Ciência, 2780-156 Oeiras, Portugal.
  • Peischl S; Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
  • Rasmussen S; Bioinformatics Research Centre, Aarhus University, 8000 Aarhus, Denmark.
  • Schiffels S; Bioinformatics Research Centre, Aarhus University, 8000 Aarhus, Denmark.
  • Subramanian S; Department of Integrative Biology, University of California, Berkeley, California 94720, USA.
  • Wright JL; Department of Integrative Biology, University of California, Berkeley, California 94720, USA.
  • Albrechtsen A; Verily Life Sciences, 2425 Garcia Ave, Mountain View, California 94043, USA.
  • Barbieri C; Research Centre for Human Evolution, Environmental Futures Research Institute, Griffith University, Nathan, Queensland 4111, Australia.
  • Dupanloup I; Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103 Leipzig, Germany.
  • Eriksson A; Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland.
  • Margaryan A; Interfaculty Bioinformatics Unit University of Bern, Baltzerstrasse 6, CH-3012 Bern, Switzerland.
  • Moltke I; Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Kemitorvet, Building 208, 2800 Kongens Lyngby, Denmark.
  • Pugach I; Department for Archaeogenetics, Max Planck Institute for the Science of Human History, Kahlaische Straße 10, D-07745 Jena, Germany.
  • Korneliussen TS; Research Centre for Human Evolution, Environmental Futures Research Institute, Griffith University, Nathan, Queensland 4111, Australia.
  • Levkivskyi IP; Research Centre for Human Evolution, Environmental Futures Research Institute, Griffith University, Nathan, Queensland 4111, Australia.
  • Moreno-Mayar JV; The Bioinformatics Centre, Department of Biology, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen, Denmark.
  • Ni S; Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103 Leipzig, Germany.
  • Racimo F; Department of Linguistic and Cultural Evolution, Max Planck Institute for the Science of Human History, Kahlaische Straße 10, D-07745 Jena, Germany.
  • Sikora M; Institute of Ecology and Evolution, University of Bern, Baltzerstrasse 6, 3012 Bern, Switzerland.
  • Xue Y; Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland.
  • Aghakhanian FA; Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK.
  • Brucato N; Integrative Systems Biology Laboratory, Division of Biological and Environmental Sciences &Engineering, King Abdullah University of Science and Technology, 23955-6900 Thuwal, Saudi Arabia.
  • Brunak S; Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5-7, 1350 Copenhagen, Denmark.
  • Campos PF; The Bioinformatics Centre, Department of Biology, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen, Denmark.
  • Clark W; Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103 Leipzig, Germany.
  • Ellingvåg S; Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5-7, 1350 Copenhagen, Denmark.
  • Fourmile G; Institute for Theoretical Physics, ETH Zürich, Wolfgang-Pauli-Str. 27, 8093 Zürich, Switzerland.
  • Gerbault P; Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5-7, 1350 Copenhagen, Denmark.
  • Injie D; Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103 Leipzig, Germany.
  • Koki G; Department of Integrative Biology, University of California, Berkeley, California 94720, USA.
  • Leavesley M; Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5-7, 1350 Copenhagen, Denmark.
  • Logan B; Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
  • Lynch A; Jeffrey Cheah School of Medicine &Health Sciences, Monash University Malaysia, Jalan Lagoon Selatan, Sunway City, 46150 Selangor, Malaysia.
  • Matisoo-Smith EA; Evolutionary Medicine Group, Laboratoire d'Anthropologie Moléculaire et Imagerie de Synthèse, UMR 5288, Centre National de la Recherche Scientifique, Université de Toulouse 3, 31073 Toulouse, France.
  • McAllister PJ; Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark.
  • Mentzer AJ; Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5-7, 1350 Copenhagen, Denmark.
  • Metspalu M; CIMAR/CIIMAR, Centro Interdisciplinar de Investigação Marinha e Ambiental, Universidade do Porto, Rua dos Bragas 289, 4050-123 Porto, Portugal.
  • Migliano AB; National Parks and Wildlife, Sturt Highway, Buronga, New South Wales 2739, Australia.
  • Murgha L; Explico Foundation, Vågavegen 16, 6900 Florø, Norway.
Nature ; 538(7624): 207-214, 2016 Oct 13.
Article in En | MEDLINE | ID: mdl-27654914
ABSTRACT
The population history of Aboriginal Australians remains largely uncharacterized. Here we generate high-coverage genomes for 83 Aboriginal Australians (speakers of Pama-Nyungan languages) and 25 Papuans from the New Guinea Highlands. We find that Papuan and Aboriginal Australian ancestors diversified 25-40 thousand years ago (kya), suggesting pre-Holocene population structure in the ancient continent of Sahul (Australia, New Guinea and Tasmania). However, all of the studied Aboriginal Australians descend from a single founding population that differentiated ~10-32 kya. We infer a population expansion in northeast Australia during the Holocene epoch (past 10,000 years) associated with limited gene flow from this region to the rest of Australia, consistent with the spread of the Pama-Nyungan languages. We estimate that Aboriginal Australians and Papuans diverged from Eurasians 51-72 kya, following a single out-of-Africa dispersal, and subsequently admixed with archaic populations. Finally, we report evidence of selection in Aboriginal Australians potentially associated with living in the desert.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phylogeny / Genome, Human / Genomics / Racial Groups / Native Hawaiian or Other Pacific Islander Limits: Humans Country/Region as subject: Africa / Oceania Language: En Journal: Nature Year: 2016 Type: Article Affiliation country: Denmark
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phylogeny / Genome, Human / Genomics / Racial Groups / Native Hawaiian or Other Pacific Islander Limits: Humans Country/Region as subject: Africa / Oceania Language: En Journal: Nature Year: 2016 Type: Article Affiliation country: Denmark