Structure-Based Reverse Vaccinology Failed in the Case of HIV Because it Disregarded Accepted Immunological Theory.

Van Regenmortel, Marc H V

Van Regenmortel, Marc H V.

Affiliation

Van Regenmortel MH; UMR 7242 Biotechnologie et Signalisation Cellulaire, Université de Strasbourg-CNRS, 300, Boulevard Sébastien Brant, CS 10413, 67412 Illkirch Cedex, France. vanregen@unistra.fr.

Int J Mol Sci ; 17(9)2016 Sep 21.

Article in En | MEDLINE | ID: mdl-27657055

Key words

V3 loop of HIV-1 spikes; antibody polyspecificity; continuous epitope; degeneracy of the immune system; discontinuous epitope; mimotope; paradigms in vaccinology; plasticity of viral proteins; rational vaccine design; structure-based reverse vaccinology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Int J Mol Sci Year: 2016 Type: Article Affiliation country: France

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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Int J Mol Sci Year: 2016 Type: Article Affiliation country: France