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FOXO3a and the MAPK p38 are activated by cetuximab to induce cell death and inhibit cell proliferation and their expression predicts cetuximab efficacy in colorectal cancer.
Marzi, L; Combes, E; Vié, N; Ayrolles-Torro, A; Tosi, D; Desigaud, D; Perez-Gracia, E; Larbouret, C; Montagut, C; Iglesias, M; Jarlier, M; Denis, V; Linares, L K; Lam, E W-F; Martineau, P; Del Rio, M; Gongora, C.
Affiliation
  • Marzi L; IRCM, Institut de Recherche en Cancérologie de Montpellier, Montpellier, F-34298, France.
  • Combes E; INSERM, U1194, Montpellier F-34298, France.
  • Vié N; Université Montpellier, Montpellier F-34298, France.
  • Ayrolles-Torro A; Institut régional du Cancer Montpellier, Montpellier F-34298, France.
  • Tosi D; IRCM, Institut de Recherche en Cancérologie de Montpellier, Montpellier, F-34298, France.
  • Desigaud D; INSERM, U1194, Montpellier F-34298, France.
  • Perez-Gracia E; Université Montpellier, Montpellier F-34298, France.
  • Larbouret C; Institut régional du Cancer Montpellier, Montpellier F-34298, France.
  • Montagut C; IRCM, Institut de Recherche en Cancérologie de Montpellier, Montpellier, F-34298, France.
  • Iglesias M; INSERM, U1194, Montpellier F-34298, France.
  • Jarlier M; Université Montpellier, Montpellier F-34298, France.
  • Denis V; Institut régional du Cancer Montpellier, Montpellier F-34298, France.
  • Linares LK; IRCM, Institut de Recherche en Cancérologie de Montpellier, Montpellier, F-34298, France.
  • Lam EW; INSERM, U1194, Montpellier F-34298, France.
  • Martineau P; Université Montpellier, Montpellier F-34298, France.
  • Del Rio M; Institut régional du Cancer Montpellier, Montpellier F-34298, France.
  • Gongora C; IRCM, Institut de Recherche en Cancérologie de Montpellier, Montpellier, F-34298, France.
Br J Cancer ; 115(10): 1223-1233, 2016 Nov 08.
Article in En | MEDLINE | ID: mdl-27685445
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colorectal Neoplasms / Cell Death / P38 Mitogen-Activated Protein Kinases / Cell Proliferation / Cetuximab / Forkhead Box Protein O3 Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Female / Humans Language: En Journal: Br J Cancer Year: 2016 Type: Article Affiliation country: France
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colorectal Neoplasms / Cell Death / P38 Mitogen-Activated Protein Kinases / Cell Proliferation / Cetuximab / Forkhead Box Protein O3 Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Female / Humans Language: En Journal: Br J Cancer Year: 2016 Type: Article Affiliation country: France