Co-application of canavanine and irradiation uncouples anticancer potential of arginine deprivation from citrulline availability.

Kurlishchuk, Yuliya; Vynnytska-Myronovska, Bozhena; Grosse-Gehling, Philipp; Bobak, Yaroslav; Manig, Friederike; Chen, Oleg; Merker, Sebastian R; Henle, Thomas; Löck, Steffen; Stange, Daniel E; Stasyk, Oleh; Kunz-Schughart, Leoni A

Kurlishchuk, Yuliya; Vynnytska-Myronovska, Bozhena; Grosse-Gehling, Philipp; Bobak, Yaroslav; Manig, Friederike; Chen, Oleg; Merker, Sebastian R; Henle, Thomas; Löck, Steffen; Stange, Daniel E; Stasyk, Oleh; Kunz-Schughart, Leoni A.

Affiliation

Kurlishchuk Y; OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, TU Dresden and Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiooncology, Dresden, Germany.
Vynnytska-Myronovska B; Department of Cell Signaling, Institute of Cell Biology, National Academy of Sciences of Ukraine, Lviv, Ukraine.
Grosse-Gehling P; OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, TU Dresden and Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiooncology, Dresden, Germany.
Bobak Y; Department of Cell Signaling, Institute of Cell Biology, National Academy of Sciences of Ukraine, Lviv, Ukraine.
Manig F; Current address: Clinic of Urology and Pediatric Urology, Saarland University Medical Center, Homburg/Saar, Germany.
Chen O; OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, TU Dresden and Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiooncology, Dresden, Germany.
Merker SR; Department of Cell Signaling, Institute of Cell Biology, National Academy of Sciences of Ukraine, Lviv, Ukraine.
Henle T; OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, TU Dresden and Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiooncology, Dresden, Germany.
Löck S; Institute of Food Chemistry, TU Dresden, Dresden, Germany.
Stange DE; OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, TU Dresden and Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiooncology, Dresden, Germany.
Stasyk O; Department of Cell Signaling, Institute of Cell Biology, National Academy of Sciences of Ukraine, Lviv, Ukraine.
Kunz-Schughart LA; Department of Gastrointestinal, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany.

Oncotarget ; 7(45): 73292-73308, 2016 Nov 08.

Article in En | MEDLINE | ID: mdl-27689335

Subject(s)

Arginine/metabolism; Canavanine/administration & dosage; Citrulline/metabolism; Radiation, Ionizing; Apoptosis/drug effects; Apoptosis/radiation effects; Argininosuccinate Synthase/genetics; Argininosuccinate Synthase/metabolism; Cell Cycle/drug effects; Cell Cycle/radiation effects; Cell Line, Tumor; Colorectal Neoplasms/metabolism; DNA Methylation/drug effects; DNA Methylation/radiation effects; Gene Expression; Humans; Intestinal Mucosa/metabolism; Intestinal Mucosa/radiation effects; Radiation Tolerance; Spheroids, Cellular; Tumor Cells, Cultured

Key words

ASS1 expression; CRC spheroids; arginine deprivation; colorectal cancer (CRC); normal colon organoids

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arginine / Radiation, Ionizing / Canavanine / Citrulline Limits: Humans Language: En Journal: Oncotarget Year: 2016 Type: Article Affiliation country: Germany

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