Bmp4-Msx1 signaling and Osr2 control tooth organogenesis through antagonistic regulation of secreted Wnt antagonists.

Jia, Shihai; Kwon, Hyuk-Jae Edward; Lan, Yu; Zhou, Jing; Liu, Han; Jiang, Rulang

Jia, Shihai; Kwon, Hyuk-Jae Edward; Lan, Yu; Zhou, Jing; Liu, Han; Jiang, Rulang.

Affiliation

Jia S; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Kwon HE; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Lan Y; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Division of Plastic Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Zhou J; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Liu H; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Jiang R; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Division of Plastic Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA. Electronic address: Rulang.Jiang@CCHMC.org.

Dev Biol ; 420(1): 110-119, 2016 Dec 01.

Article in En | MEDLINE | ID: mdl-27713059

Subject(s)

Bone Morphogenetic Protein 4/metabolism; Intercellular Signaling Peptides and Proteins/metabolism; MSX1 Transcription Factor/metabolism; Membrane Proteins/metabolism; Organogenesis; Signal Transduction; Tooth/embryology; Wnt Proteins/antagonists & inhibitors; Animals; Gene Expression Regulation, Developmental/drug effects; Intercellular Signaling Peptides and Proteins/genetics; Lithium Chloride/pharmacology; Mandible/drug effects; Mandible/embryology; Mandible/metabolism; Membrane Proteins/genetics; Mice, Knockout; Molar/drug effects; Molar/embryology; Molar/metabolism; Morphogenesis/drug effects; Organogenesis/drug effects; RNA, Messenger/genetics; RNA, Messenger/metabolism; Signal Transduction/drug effects; Signal Transduction/genetics; Tooth/drug effects; Tooth/metabolism; Tooth Germ/drug effects; Tooth Germ/embryology; Tooth Germ/metabolism; Transcription Factors; Wnt Proteins/metabolism

Key words

Bmp4; Dkk2; Mouse; Msx1; Organogenesis; Osr2; Sfrp2; Tooth development; Wnt signaling

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tooth / Signal Transduction / Intercellular Signaling Peptides and Proteins / Organogenesis / Wnt Proteins / MSX1 Transcription Factor / Bone Morphogenetic Protein 4 / Membrane Proteins Limits: Animals Language: En Journal: Dev Biol Year: 2016 Type: Article Affiliation country: United States

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