Deguelin and Its Role in Chronic Diseases.

Boyd, Jonathan; Han, Alice

Boyd, Jonathan; Han, Alice.

Affiliation

Boyd J; C. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, West Virginia, USA. Jonathan.boyd@mail.wvu.edu.
Han A; C. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, West Virginia, USA.

Adv Exp Med Biol ; 929: 363-375, 2016.

Article in En | MEDLINE | ID: mdl-27771933

Subject(s)

Antineoplastic Agents, Phytogenic/therapeutic use; Antioxidants/therapeutic use; Chronic Disease/drug therapy; Drug Discovery/methods; Electron Transport Complex I/antagonists & inhibitors; Enzyme Inhibitors/therapeutic use; Rotenone/analogs & derivatives; Animals; Antineoplastic Agents, Phytogenic/adverse effects; Antineoplastic Agents, Phytogenic/chemistry; Antioxidants/adverse effects; Antioxidants/chemistry; Disease Models, Animal; Electron Transport Complex I/metabolism; Enzyme Inhibitors/adverse effects; Enzyme Inhibitors/chemistry; Humans; Molecular Structure; Parkinson Disease, Secondary/chemically induced; Phytotherapy; Plants, Medicinal; Risk Factors; Rotenone/adverse effects; Rotenone/chemistry; Rotenone/therapeutic use; Signal Transduction/drug effects

Key words

Apoptosis; Cell cycle arrest; Chemopreventive; Chemotherapeutic; Deguelin; Mitochondrial complex I inhibitor; Parkinson's disease

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PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Rotenone / Chronic Disease / Electron Transport Complex I / Enzyme Inhibitors / Drug Discovery / Antineoplastic Agents, Phytogenic / Antioxidants Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: Adv Exp Med Biol Year: 2016 Type: Article Affiliation country: United States

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