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BET Inhibitors Suppress ALDH Activity by Targeting ALDH1A1 Super-Enhancer in Ovarian Cancer.
Yokoyama, Yuhki; Zhu, Hengrui; Lee, Jeong Heon; Kossenkov, Andrew V; Wu, Sherry Y; Wickramasinghe, Jayamanna M; Yin, Xiangfan; Palozola, Katherine C; Gardini, Alessandro; Showe, Louise C; Zaret, Kenneth S; Liu, Qin; Speicher, David; Conejo-Garcia, Jose R; Bradner, James E; Zhang, Zhiguo; Sood, Anil K; Ordog, Tamas; Bitler, Benjamin G; Zhang, Rugang.
Affiliation
  • Yokoyama Y; Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, Pennsylvania.
  • Zhu H; Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, Pennsylvania.
  • Lee JH; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota.
  • Kossenkov AV; Center for Systems and Computational Biology, The Wistar Institute, Philadelphia, Pennsylvania.
  • Wu SY; Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Wickramasinghe JM; Center for RNAi and Non-Coding RNA, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Yin X; Center for Systems and Computational Biology, The Wistar Institute, Philadelphia, Pennsylvania.
  • Palozola KC; Molecular and Cellular Oncology Program, The Wistar Institute, Philadelphia, Pennsylvania.
  • Gardini A; Institute for Regenerative Medicine, Epigenetics Program, and Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Pennsylvania.
  • Showe LC; Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, Pennsylvania.
  • Zaret KS; Center for Systems and Computational Biology, The Wistar Institute, Philadelphia, Pennsylvania.
  • Liu Q; Molecular and Cellular Oncology Program, The Wistar Institute, Philadelphia, Pennsylvania.
  • Speicher D; Institute for Regenerative Medicine, Epigenetics Program, and Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Pennsylvania.
  • Conejo-Garcia JR; Molecular and Cellular Oncology Program, The Wistar Institute, Philadelphia, Pennsylvania.
  • Bradner JE; Molecular and Cellular Oncology Program, The Wistar Institute, Philadelphia, Pennsylvania.
  • Zhang Z; Tumor Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, Pennsylvania.
  • Sood AK; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.
  • Ordog T; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota.
  • Bitler BG; Mayo Clinic, Rochester, Minnesota.
  • Zhang R; Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Cancer Res ; 76(21): 6320-6330, 2016 11 01.
Article in En | MEDLINE | ID: mdl-27803105
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ovarian Neoplasms / Azepines / Transcription Factors / Triazoles / Nuclear Proteins / Neoplasms, Glandular and Epithelial / Aldehyde Dehydrogenase Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Cancer Res Year: 2016 Type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ovarian Neoplasms / Azepines / Transcription Factors / Triazoles / Nuclear Proteins / Neoplasms, Glandular and Epithelial / Aldehyde Dehydrogenase Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Cancer Res Year: 2016 Type: Article