Fragment-based approaches to TB drugs.
Parasitology
; 145(2): 184-195, 2018 02.
Article
in En
| MEDLINE
| ID: mdl-27804891
ABSTRACT
Tuberculosis is an infectious disease associated with significant mortality and morbidity worldwide, particularly in developing countries. The rise of antibiotic resistance in Mycobacterium tuberculosis (Mtb) urgently demands the development of new drug leads to tackle resistant strains. Fragment-based methods have recently emerged at the forefront of pharmaceutical development as a means to generate more effective lead structures, via the identification of fragment molecules that form weak but high quality interactions with the target biomolecule and subsequent fragment optimization. This review highlights a number of novel inhibitors of Mtb targets that have been developed through fragment-based approaches in recent years.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Bacterial Proteins
/
Tuberculosis
/
Drug Discovery
/
Mycobacterium tuberculosis
Type of study:
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
Parasitology
Year:
2018
Type:
Article
Affiliation country:
United kingdom