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Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition.
Frost, Julianty; Galdeano, Carles; Soares, Pedro; Gadd, Morgan S; Grzes, Katarzyna M; Ellis, Lucy; Epemolu, Ola; Shimamura, Satoko; Bantscheff, Marcus; Grandi, Paola; Read, Kevin D; Cantrell, Doreen A; Rocha, Sonia; Ciulli, Alessio.
Affiliation
  • Frost J; Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK.
  • Galdeano C; Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK.
  • Soares P; Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK.
  • Gadd MS; Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK.
  • Grzes KM; Division of Cell Signaling and Immunology, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK.
  • Ellis L; Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK.
  • Epemolu O; Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK.
  • Shimamura S; Cellzome GmbH, Meyerhofstrasse 1, 69117 Heidelberg, Germany.
  • Bantscheff M; Cellzome GmbH, Meyerhofstrasse 1, 69117 Heidelberg, Germany.
  • Grandi P; Cellzome GmbH, Meyerhofstrasse 1, 69117 Heidelberg, Germany.
  • Read KD; Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK.
  • Cantrell DA; Division of Cell Signaling and Immunology, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK.
  • Rocha S; Center for Gene Regulation and Expression, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK.
  • Ciulli A; Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK.
Nat Commun ; 7: 13312, 2016 11 04.
Article in En | MEDLINE | ID: mdl-27811928
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrrolidines / Thiazoles / Signal Transduction / Cell Hypoxia / Cyclopropanes / Enzyme Inhibitors / Von Hippel-Lindau Tumor Suppressor Protein / Hypoxia-Inducible Factor 1, alpha Subunit Limits: Animals / Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2016 Type: Article Affiliation country: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrrolidines / Thiazoles / Signal Transduction / Cell Hypoxia / Cyclopropanes / Enzyme Inhibitors / Von Hippel-Lindau Tumor Suppressor Protein / Hypoxia-Inducible Factor 1, alpha Subunit Limits: Animals / Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2016 Type: Article Affiliation country: United kingdom