Baby hamster kidney cell-derived recombinant factor VIII: a quarter century of learning and clinical experience.

Afonja, Olubunmi; Kozak, Robert; Petraro, Paul; Michaels, Lisa A; Mathew, Prasad; Lemm, Georg; Kessler, Craig

Afonja, Olubunmi; Kozak, Robert; Petraro, Paul; Michaels, Lisa A; Mathew, Prasad; Lemm, Georg; Kessler, Craig.

Affiliation

Afonja O; a Bayer , Whippany , NJ , USA.
Kozak R; b Bayer , Berkeley , CA , USA.
Petraro P; a Bayer , Whippany , NJ , USA.
Michaels LA; a Bayer , Whippany , NJ , USA.
Mathew P; a Bayer , Whippany , NJ , USA.
Lemm G; c Department of Pediatric Hematology/Oncology , University of New Mexico , Albuquerque , NM , USA.
Kessler C; d Bayer Pharma AG , Wuppertal , Germany.

Expert Rev Hematol ; 9(12): 1151-1164, 2016 Dec.

Article in En | MEDLINE | ID: mdl-27841041

Subject(s)

Factor VIII/therapeutic use; Hemophilia A/drug therapy; Recombinant Proteins/therapeutic use; Animals; Antibodies/immunology; Blood Coagulation Factor Inhibitors; Blood Coagulation Tests; CHO Cells; Cell Line; Cricetinae; Cricetulus; Factor VIII/pharmacology; Hemophilia A/blood; Humans; Protein Engineering; Protein Processing, Post-Translational; Recombinant Proteins/pharmacology; Treatment Outcome

Key words

Hemophilia; baby hamster kidney cell line; clinical efficacy; immunogenicity; prophylaxis; recombinant factor VIII

Search on Google

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Recombinant Proteins / Factor VIII / Hemophilia A Type of study: Guideline / Observational_studies Limits: Animals / Humans Language: En Journal: Expert Rev Hematol Journal subject: HEMATOLOGIA Year: 2016 Type: Article Affiliation country: United States

Search on Google

XML

PubMed Links