Increased risk for urological cancer associated with anxiety disorder: a retrospective cohort study.
BMC Urol
; 16(1): 67, 2016 Nov 16.
Article
in En
| MEDLINE
| ID: mdl-27852299
ABSTRACT
BACKGROUND:
Anxiety disorders (ADs) are common with a high rate of medical comorbidities. Although the association between ADs and the overall cancer risk remains controversial, patients with ADs were found to be more likely to develop specific cancer types. Herein, we estimated the risk of developing urological cancers among patients with ADs in a 5-year follow-up period using a population-based database.METHODS:
Two study cohorts were identified from the Taiwan Longitudinal Health Insurance Database 2005 patients with ADs, and comparison subjects selected by one-to-one matching for sex, age, and the year of recruitment. Follow-up was undertaken to determine whether sampled patients and comparison subjects had developed urological cancers in the subsequent 5 years.RESULTS:
We found that urological cancers occurred among 0.54% of patients with ADs and 0.13% of comparison subjects. After adjusting for sociodemographic characteristics, medical comorbidities, and alcohol and tobacco use disorder, the stratified Cox proportional hazard regression suggested that patients with ADs were more likely to develop urological cancers relative to comparison subjects (adjusted hazard ratio, 3.67; 95% confidence interval, 2.85 ~ 4.72). The adjusted HR for males with ADs was 3.82 (95% CI 2.79 ~ 5.23) in comparison to males without ADs. In addition, the adjusted HR for females with ADs was 3.47 (95% CI 2.26 ~ 5.31) than those females without ADs.CONCLUSIONS:
We concluded that during the 5-year follow-up period, there was a significantly increased risk of urological cancers among patients with ADs.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Anxiety Disorders
/
Urologic Neoplasms
Type of study:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
BMC Urol
Journal subject:
UROLOGIA
Year:
2016
Type:
Article
Affiliation country:
Taiwan