Sensitivity of TP53-Mutated Cancer Cells to the Phytoestrogen Genistein Is Associated With Direct Inhibition of Plk1 Activity.

Shin, Sol-Bi; Woo, Sang-Uk; Chin, Young-Won; Jang, Young-Joo; Yim, Hyungshin

Shin, Sol-Bi; Woo, Sang-Uk; Chin, Young-Won; Jang, Young-Joo; Yim, Hyungshin.

Affiliation

Shin SB; Department of Pharmacy, College of Pharmacy, Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan, Gyeonggi-do, Korea.
Woo SU; Department of Pharmacy, College of Pharmacy, Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan, Gyeonggi-do, Korea.
Chin YW; College of Pharmacy and Integrated Research Institute for Drug Development, Dongguk University-Seoul, Goyang, Gyeonggi-do, Korea.
Jang YJ; Department of Nanobiomedical Science and BK21 PLUS Global Research Center for Regenerative Medicine, Dankook University, Cheonan, Korea.
Yim H; Department of Pharmacy, College of Pharmacy, Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan, Gyeonggi-do, Korea.

J Cell Physiol ; 232(10): 2818-2828, 2017 Oct.

Article in En | MEDLINE | ID: mdl-27861885

Subject(s)

Antineoplastic Agents, Hormonal/pharmacology; Cell Cycle Proteins/antagonists & inhibitors; Cell Proliferation/drug effects; Genistein/pharmacology; Mutation; Neoplasms/drug therapy; Phytoestrogens/pharmacology; Protein Kinase Inhibitors/pharmacology; Protein Serine-Threonine Kinases/antagonists & inhibitors; Proto-Oncogene Proteins/antagonists & inhibitors; Tumor Suppressor Protein p53/genetics; Apoptosis/drug effects; Cell Cycle Proteins/metabolism; Cell Survival/drug effects; Dose-Response Relationship, Drug; ErbB Receptors/antagonists & inhibitors; ErbB Receptors/metabolism; G2 Phase Cell Cycle Checkpoints/drug effects; HCT116 Cells; Hep G2 Cells; Humans; Inhibitory Concentration 50; MCF-7 Cells; Neoplasms/enzymology; Neoplasms/genetics; Neoplasms/pathology; Protein Serine-Threonine Kinases/metabolism; Proto-Oncogene Proteins/metabolism; RNA Interference; Signal Transduction/drug effects; Transfection; Tumor Suppressor Protein p53/metabolism; Polo-Like Kinase 1

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tumor Suppressor Protein p53 / Proto-Oncogene Proteins / Protein Serine-Threonine Kinases / Cell Cycle Proteins / Antineoplastic Agents, Hormonal / Genistein / Protein Kinase Inhibitors / Phytoestrogens / Cell Proliferation / Mutation Type of study: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: J Cell Physiol Year: 2017 Type: Article

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