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Pharmacologic modulation of RORγt translates to efficacy in preclinical and translational models of psoriasis and inflammatory arthritis.
Xue, Xiaohua; Soroosh, Pejman; De Leon-Tabaldo, Aimee; Luna-Roman, Rosa; Sablad, Marciano; Rozenkrants, Natasha; Yu, Jingxue; Castro, Glenda; Banie, Homayon; Fung-Leung, Wai-Ping; Santamaria-Babi, Luis; Schlueter, Thomas; Albers, Michael; Leonard, Kristi; Budelsky, Alison L; Fourie, Anne M.
Affiliation
  • Xue X; Janssen Research &Development, La Jolla, California, United States.
  • Soroosh P; Janssen Research &Development, La Jolla, California, United States.
  • De Leon-Tabaldo A; Janssen Research &Development, La Jolla, California, United States.
  • Luna-Roman R; Janssen Research &Development, La Jolla, California, United States.
  • Sablad M; Janssen Research &Development, La Jolla, California, United States.
  • Rozenkrants N; Janssen Research &Development, La Jolla, California, United States.
  • Yu J; Janssen Research &Development, La Jolla, California, United States.
  • Castro G; Janssen Research &Development, La Jolla, California, United States.
  • Banie H; Janssen Research &Development, La Jolla, California, United States.
  • Fung-Leung WP; Janssen Research &Development, La Jolla, California, United States.
  • Santamaria-Babi L; Translational Immunology (PCB/UB), Department of Physiology and Immunology, Universitat de Barcelona Barcelona, Spain.
  • Schlueter T; Department of Research, Phenex Pharmaceuticals AG, Heidelberg, Germany.
  • Albers M; Department of Research, Phenex Pharmaceuticals AG, Heidelberg, Germany.
  • Leonard K; Janssen Research &Development, Spring House, Pennsylvania, United States.
  • Budelsky AL; Janssen Research &Development, La Jolla, California, United States.
  • Fourie AM; Janssen Research &Development, La Jolla, California, United States.
Sci Rep ; 6: 37977, 2016 12 01.
Article in En | MEDLINE | ID: mdl-27905482
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides, Cyclic / Arthritis, Rheumatoid / Psoriasis / Nuclear Receptor Subfamily 1, Group F, Member 3 / Th17 Cells Limits: Animals Language: En Journal: Sci Rep Year: 2016 Type: Article Affiliation country: United States
Fulltext
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PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides, Cyclic / Arthritis, Rheumatoid / Psoriasis / Nuclear Receptor Subfamily 1, Group F, Member 3 / Th17 Cells Limits: Animals Language: En Journal: Sci Rep Year: 2016 Type: Article Affiliation country: United States