Covalent inhibition of carboxylesterase-2 by sofosbuvir and its effect on the hydrolytic activation of tenofovir disoproxil.

Shen, Yuanjun; Yan, Bingfang

Shen, Yuanjun; Yan, Bingfang.

Affiliation

Shen Y; Department of Biomedical Sciences, Center for Integrated Drug Development, University of Rhode Island, Kingston, RI 02881, USA.
Yan B; Department of Biomedical Sciences, Center for Integrated Drug Development, University of Rhode Island, Kingston, RI 02881, USA. Electronic address: byan@uri.edu.

J Hepatol ; 66(3): 660-661, 2017 03.

Article in En | MEDLINE | ID: mdl-27965153

Subject(s)

Carboxylesterase/metabolism; Carboxylic Ester Hydrolases/metabolism; Kidney; Microsomes, Liver/metabolism; Sofosbuvir/pharmacology; Tenofovir/pharmacology; Anti-HIV Agents/pharmacology; Antiviral Agents/pharmacology; Cell Fractionation; Chromatography, Liquid; Drug Interactions; Humans; Hydrolysis/drug effects; Kidney/pathology; Kidney/ultrastructure

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Microsomes, Liver / Carboxylic Ester Hydrolases / Carboxylesterase / Tenofovir / Sofosbuvir / Kidney Limits: Humans Language: En Journal: J Hepatol Journal subject: GASTROENTEROLOGIA Year: 2017 Type: Article Affiliation country: United States

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