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AML associated oncofusion proteins PML-RARA, AML1-ETO and CBFB-MYH11 target RUNX/ETS-factor binding sites to modulate H3ac levels and drive leukemogenesis.
Singh, Abhishek A; Mandoli, Amit; Prange, Koen H M; Laakso, Marko; Martens, Joost H A.
Affiliation
  • Singh AA; Radboud University, Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, 6500 HB Nijmegen, The Netherlands.
  • Mandoli A; Radboud University, Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, 6500 HB Nijmegen, The Netherlands.
  • Prange KH; Radboud University, Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, 6500 HB Nijmegen, The Netherlands.
  • Laakso M; Genome Scale Biology Research Program, Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
  • Martens JH; Radboud University, Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, 6500 HB Nijmegen, The Netherlands.
Oncotarget ; 8(8): 12855-12865, 2017 Feb 21.
Article in En | MEDLINE | ID: mdl-28030795
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Histones / Leukemia, Myeloid, Acute / Gene Expression Regulation, Leukemic / Oncogene Proteins, Fusion Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Oncotarget Year: 2017 Type: Article Affiliation country: Netherlands
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Histones / Leukemia, Myeloid, Acute / Gene Expression Regulation, Leukemic / Oncogene Proteins, Fusion Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Oncotarget Year: 2017 Type: Article Affiliation country: Netherlands