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Development of a Convenient In Vitro Gel Diffusion Model for Predicting the In Vivo Performance of Subcutaneous Parenteral Formulations of Large and Small Molecules.
Leung, Dennis H; Kapoor, Yash; Alleyne, Candice; Walsh, Erika; Leithead, Andrew; Habulihaz, Bahanu; Salituro, Gino M; Bak, Annette; Rhodes, Timothy.
Affiliation
  • Leung DH; Discovery Pharmaceutical Sciences, Merck & Co., Inc., 126 E. Lincoln Ave., Rahway, New Jersey, 07065, USA. leung.dennis@gene.com.
  • Kapoor Y; Small Molecule Pharmaceutical Sciences, Genentech Inc., 1 DNA Way, South San Francisco, California, 94080, USA. leung.dennis@gene.com.
  • Alleyne C; Formulation Sciences, Merck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania, 19486, USA.
  • Walsh E; Discovery Pharmaceutical Sciences, Merck & Co., Inc., 126 E. Lincoln Ave., Rahway, New Jersey, 07065, USA.
  • Leithead A; Discovery Pharmaceutical Sciences, Merck & Co., Inc., 126 E. Lincoln Ave., Rahway, New Jersey, 07065, USA.
  • Habulihaz B; Discovery Pharmaceutical Sciences, Merck & Co., Inc., 126 E. Lincoln Ave., Rahway, New Jersey, 07065, USA.
  • Salituro GM; Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Inc., 126 E. Lincoln Ave., Rahway, New Jersey, 07065, USA.
  • Bak A; Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Inc., 126 E. Lincoln Ave., Rahway, New Jersey, 07065, USA.
  • Rhodes T; Discovery Pharmaceutical Sciences, Merck & Co., Inc., 126 E. Lincoln Ave., Rahway, New Jersey, 07065, USA.
AAPS PharmSciTech ; 18(6): 2203-2213, 2017 Aug.
Article in En | MEDLINE | ID: mdl-28070846
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sepharose / Drug Delivery Systems Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: AAPS PharmSciTech Journal subject: FARMACOLOGIA Year: 2017 Type: Article Affiliation country: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sepharose / Drug Delivery Systems Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: AAPS PharmSciTech Journal subject: FARMACOLOGIA Year: 2017 Type: Article Affiliation country: United States