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Tau interactome mapping based identification of Otub1 as Tau deubiquitinase involved in accumulation of pathological Tau forms in vitro and in vivo.
Wang, Peng; Joberty, Gerard; Buist, Arjan; Vanoosthuyse, Alexandre; Stancu, Ilie-Cosmin; Vasconcelos, Bruno; Pierrot, Nathalie; Faelth-Savitski, Maria; Kienlen-Campard, Pascal; Octave, Jean-Noël; Bantscheff, Marcus; Drewes, Gerard; Moechars, Diederik; Dewachter, Ilse.
Affiliation
  • Wang P; Alzheimer Dementia Group, Institute of Neuroscience, Catholic University of Louvain, 1200, Brussels, Belgium.
  • Joberty G; Cellzome GmbH, Molecular Discovery Research, GlaxoSmithKline, Meyerhofstrasse 1, Heidelberg, Germany.
  • Buist A; Department of Neuroscience, Janssen Research and Development, A Division of Janssen Pharmaceutica NV, 2340, Beerse, Belgium.
  • Vanoosthuyse A; Alzheimer Dementia Group, Institute of Neuroscience, Catholic University of Louvain, 1200, Brussels, Belgium.
  • Stancu IC; Alzheimer Dementia Group, Institute of Neuroscience, Catholic University of Louvain, 1200, Brussels, Belgium.
  • Vasconcelos B; Alzheimer Dementia Group, Institute of Neuroscience, Catholic University of Louvain, 1200, Brussels, Belgium.
  • Pierrot N; Alzheimer Dementia Group, Institute of Neuroscience, Catholic University of Louvain, 1200, Brussels, Belgium.
  • Faelth-Savitski M; Cellzome GmbH, Molecular Discovery Research, GlaxoSmithKline, Meyerhofstrasse 1, Heidelberg, Germany.
  • Kienlen-Campard P; Alzheimer Dementia Group, Institute of Neuroscience, Catholic University of Louvain, 1200, Brussels, Belgium.
  • Octave JN; Alzheimer Dementia Group, Institute of Neuroscience, Catholic University of Louvain, 1200, Brussels, Belgium.
  • Bantscheff M; Cellzome GmbH, Molecular Discovery Research, GlaxoSmithKline, Meyerhofstrasse 1, Heidelberg, Germany.
  • Drewes G; Cellzome GmbH, Molecular Discovery Research, GlaxoSmithKline, Meyerhofstrasse 1, Heidelberg, Germany.
  • Moechars D; Department of Neuroscience, Janssen Research and Development, A Division of Janssen Pharmaceutica NV, 2340, Beerse, Belgium.
  • Dewachter I; Alzheimer Dementia Group, Institute of Neuroscience, Catholic University of Louvain, 1200, Brussels, Belgium. ilse.dewachter@uclouvain.be.
Acta Neuropathol ; 133(5): 731-749, 2017 05.
Article in En | MEDLINE | ID: mdl-28083634

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cysteine Endopeptidases / Neurofibrillary Tangles / Tau Proteins / Tauopathies / Deubiquitinating Enzymes Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals / Humans Language: En Journal: Acta Neuropathol Year: 2017 Type: Article Affiliation country: Belgium

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cysteine Endopeptidases / Neurofibrillary Tangles / Tau Proteins / Tauopathies / Deubiquitinating Enzymes Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals / Humans Language: En Journal: Acta Neuropathol Year: 2017 Type: Article Affiliation country: Belgium