Chondroitin sulfates and their binding molecules in the central nervous system.
Glycoconj J
; 34(3): 363-376, 2017 06.
Article
in En
| MEDLINE
| ID: mdl-28101734
ABSTRACT
Chondroitin sulfate (CS) is the most abundant glycosaminoglycan (GAG) in the central nervous system (CNS) matrix. Its sulfation and epimerization patterns give rise to different forms of CS, which enables it to interact specifically and with a significant affinity with various signalling molecules in the matrix including growth factors, receptors and guidance molecules. These interactions control numerous biological and pathological processes, during development and in adulthood. In this review, we describe the specific interactions of different families of proteins involved in various physiological and cognitive mechanisms with CSs in CNS matrix. A better understanding of these interactions could promote a development of inhibitors to treat neurodegenerative diseases.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Central Nervous System
/
Chondroitin Sulfates
/
Extracellular Matrix Proteins
/
Neural Cell Adhesion Molecules
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Intercellular Signaling Peptides and Proteins
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Neurons
Limits:
Animals
/
Humans
Language:
En
Journal:
Glycoconj J
Journal subject:
BIOQUIMICA
/
METABOLISMO
Year:
2017
Type:
Article
Affiliation country:
France