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Detoxification of benzo[a]pyrene primarily depends on cytochrome P450, while bioactivation involves additional oxidoreductases including 5-lipoxygenase, cyclooxygenase, and aldo-keto reductase in the liver.
Wang, Liupeng; Xu, Wenwei; Ma, Leilei; Zhang, Suxing; Zhang, Kezhi; Ye, Peizhen; Xing, Guozhen; Zhang, Xuefeng; Cao, Yiyi; Xi, Jing; Gu, Jun; Luan, Yang.
Affiliation
  • Wang L; Hongqiao International Institute of Medicine, Shanghai Tong Ren Hospital and Faculty of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, People's Republic of China.
  • Xu W; Tong Ren Hospital Affiliated To Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, People's Republic of China.
  • Ma L; Hongqiao International Institute of Medicine, Shanghai Tong Ren Hospital and Faculty of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, People's Republic of China.
  • Zhang S; KG Pharma Limited, Foshan, 528000, People's Republic of China.
  • Zhang K; KG Pharma Limited, Foshan, 528000, People's Republic of China.
  • Ye P; KG Pharma Limited, Foshan, 528000, People's Republic of China.
  • Xing G; Jiangsu Tripod Preclinical Research Laboratories, Pukou Economic Development Zone, Nanjing, People's Republic of China.
  • Zhang X; Jiangsu Tripod Preclinical Research Laboratories, Pukou Economic Development Zone, Nanjing, People's Republic of China.
  • Cao Y; Hongqiao International Institute of Medicine, Shanghai Tong Ren Hospital and Faculty of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, People's Republic of China.
  • Xi J; Hongqiao International Institute of Medicine, Shanghai Tong Ren Hospital and Faculty of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, People's Republic of China.
  • Gu J; Wadsworth Center, New York State Department of Health, Albany, NY, 12201-0509, USA.
  • Luan Y; Hongqiao International Institute of Medicine, Shanghai Tong Ren Hospital and Faculty of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, People's Republic of China.
J Biochem Mol Toxicol ; 31(7)2017 Jul.
Article in En | MEDLINE | ID: mdl-28111842
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzo(a)pyrene / Arachidonate 5-Lipoxygenase / Cytochrome P-450 Enzyme System / Aldo-Keto Reductases / Liver Limits: Animals Language: En Journal: J Biochem Mol Toxicol Journal subject: BIOLOGIA MOLECULAR / BIOQUIMICA / TOXICOLOGIA Year: 2017 Type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzo(a)pyrene / Arachidonate 5-Lipoxygenase / Cytochrome P-450 Enzyme System / Aldo-Keto Reductases / Liver Limits: Animals Language: En Journal: J Biochem Mol Toxicol Journal subject: BIOLOGIA MOLECULAR / BIOQUIMICA / TOXICOLOGIA Year: 2017 Type: Article