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The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity.
Bromberg, Kenneth D; Mitchell, Taylor R H; Upadhyay, Anup K; Jakob, Clarissa G; Jhala, Manisha A; Comess, Kenneth M; Lasko, Loren M; Li, Conglei; Tuzon, Creighton T; Dai, Yujia; Li, Fengling; Eram, Mohammad S; Nuber, Alexander; Soni, Niru B; Manaves, Vlasios; Algire, Mikkel A; Sweis, Ramzi F; Torrent, Maricel; Schotta, Gunnar; Sun, Chaohong; Michaelides, Michael R; Shoemaker, Alex R; Arrowsmith, Cheryl H; Brown, Peter J; Santhakumar, Vijayaratnam; Martin, Alberto; Rice, Judd C; Chiang, Gary G; Vedadi, Masoud; Barsyte-Lovejoy, Dalia; Pappano, William N.
Affiliation
  • Bromberg KD; Discovery, Research and Development, AbbVie, North Chicago, Illinois, USA.
  • Mitchell TR; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.
  • Upadhyay AK; Discovery, Research and Development, AbbVie, North Chicago, Illinois, USA.
  • Jakob CG; Discovery, Research and Development, AbbVie, North Chicago, Illinois, USA.
  • Jhala MA; Discovery, Research and Development, AbbVie, North Chicago, Illinois, USA.
  • Comess KM; Discovery, Research and Development, AbbVie, North Chicago, Illinois, USA.
  • Lasko LM; Discovery, Research and Development, AbbVie, North Chicago, Illinois, USA.
  • Li C; Department of Immunology, University of Toronto, Medical Sciences Building, Toronto, Canada.
  • Tuzon CT; Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA.
  • Dai Y; Discovery, Research and Development, AbbVie, North Chicago, Illinois, USA.
  • Li F; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.
  • Eram MS; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.
  • Nuber A; Ludwig-Maximilians-Universität München and Munich Center for Integrated Protein Science (CiPSM), Biomedical Center, Planegg-Martinsried, Germany.
  • Soni NB; Discovery, Research and Development, AbbVie, North Chicago, Illinois, USA.
  • Manaves V; Discovery, Research and Development, AbbVie, North Chicago, Illinois, USA.
  • Algire MA; Discovery, Research and Development, AbbVie, North Chicago, Illinois, USA.
  • Sweis RF; Discovery, Research and Development, AbbVie, North Chicago, Illinois, USA.
  • Torrent M; Discovery, Research and Development, AbbVie, North Chicago, Illinois, USA.
  • Schotta G; Ludwig-Maximilians-Universität München and Munich Center for Integrated Protein Science (CiPSM), Biomedical Center, Planegg-Martinsried, Germany.
  • Sun C; Discovery, Research and Development, AbbVie, North Chicago, Illinois, USA.
  • Michaelides MR; Discovery, Research and Development, AbbVie, North Chicago, Illinois, USA.
  • Shoemaker AR; Discovery, Research and Development, AbbVie, North Chicago, Illinois, USA.
  • Arrowsmith CH; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.
  • Brown PJ; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.
  • Santhakumar V; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.
  • Martin A; Department of Immunology, University of Toronto, Medical Sciences Building, Toronto, Canada.
  • Rice JC; Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA.
  • Chiang GG; Discovery, Research and Development, AbbVie, North Chicago, Illinois, USA.
  • Vedadi M; eFFECTOR Therapeutics, San Diego, California, USA.
  • Barsyte-Lovejoy D; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.
  • Pappano WN; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.
Nat Chem Biol ; 13(3): 317-324, 2017 03.
Article in En | MEDLINE | ID: mdl-28114273
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Histone-Lysine N-Methyltransferase / Genomic Instability / Epigenesis, Genetic / Enzyme Inhibitors / Heterocyclic Compounds, 4 or More Rings Limits: Humans Language: En Journal: Nat Chem Biol Journal subject: BIOLOGIA / QUIMICA Year: 2017 Type: Article Affiliation country: United States
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Histone-Lysine N-Methyltransferase / Genomic Instability / Epigenesis, Genetic / Enzyme Inhibitors / Heterocyclic Compounds, 4 or More Rings Limits: Humans Language: En Journal: Nat Chem Biol Journal subject: BIOLOGIA / QUIMICA Year: 2017 Type: Article Affiliation country: United States