Structural Studies of Amyloid Proteins at the Molecular Level.

Eisenberg, David S; Sawaya, Michael R

Eisenberg, David S; Sawaya, Michael R.

Affiliation

Eisenberg DS; Howard Hughes Medical Institute and Molecular Biology Institute, University of California, Los Angeles, California 90095-1570; email: david@mbi.ucla.edu , sawaya@mbi.ucla.edu.
Sawaya MR; Howard Hughes Medical Institute and Molecular Biology Institute, University of California, Los Angeles, California 90095-1570; email: david@mbi.ucla.edu , sawaya@mbi.ucla.edu.

Annu Rev Biochem ; 86: 69-95, 2017 06 20.

Article in En | MEDLINE | ID: mdl-28125289

Subject(s)

Amyloidogenic Proteins/chemistry; Prion Proteins/chemistry; Protein Aggregation, Pathological/metabolism; Amino Acid Motifs; Amyloidogenic Proteins/genetics; Amyloidogenic Proteins/metabolism; Animals; Cryoelectron Microscopy; Gene Expression; Humans; Nuclear Magnetic Resonance, Biomolecular; Prion Proteins/genetics; Prion Proteins/metabolism; Protein Aggregation, Pathological/genetics; Protein Aggregation, Pathological/pathology; Protein Denaturation; Protein Multimerization; Protein Stability; Protein Structure, Secondary; X-Ray Diffraction

Key words

X-ray diffraction; amyloid symmetry; cryo-EM; cryoelectron microscopy; polymorphs; solid-state nuclear magnetic resonance; ssNMR; steric zipper

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Amyloidogenic Proteins / Protein Aggregation, Pathological / Prion Proteins Limits: Animals / Humans Language: En Journal: Annu Rev Biochem Year: 2017 Type: Article

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