Carbon monoxide releasing molecule-3 improves myocardial function in mice with sepsis by inhibiting NLRP3 inflammasome activation in cardiac fibroblasts.

Zhang, Wenbo; Tao, Aibin; Lan, Ting; Cepinskas, Gediminas; Kao, Raymond; Martin, Claudio M; Rui, Tao

Zhang, Wenbo; Tao, Aibin; Lan, Ting; Cepinskas, Gediminas; Kao, Raymond; Martin, Claudio M; Rui, Tao.

Affiliation

Zhang W; Division of Cardiology, Department of Medicine, The Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu, People's Republic of China.
Tao A; Critical Illness Research, Lawson Health Research Institute, 800 Commissioners Road E., VRL Rm A6-138, London, ON, N6A 4G5, Canada.
Lan T; Division of Cardiology, Department of Medicine, The Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu, People's Republic of China.
Cepinskas G; Critical Illness Research, Lawson Health Research Institute, 800 Commissioners Road E., VRL Rm A6-138, London, ON, N6A 4G5, Canada.
Kao R; Critical Illness Research, Lawson Health Research Institute, 800 Commissioners Road E., VRL Rm A6-138, London, ON, N6A 4G5, Canada.
Martin CM; Critical Illness Research, Lawson Health Research Institute, 800 Commissioners Road E., VRL Rm A6-138, London, ON, N6A 4G5, Canada.
Rui T; Critical Illness Research, Lawson Health Research Institute, 800 Commissioners Road E., VRL Rm A6-138, London, ON, N6A 4G5, Canada.

Basic Res Cardiol ; 112(2): 16, 2017 03.

Article in En | MEDLINE | ID: mdl-28168403

Subject(s)

Fibroblasts/metabolism; Inflammasomes/drug effects; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism; Organometallic Compounds/pharmacology; Sepsis/complications; Animals; Apoptosis/physiology; Blotting, Western; Carbon Monoxide/pharmacology; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Fibroblasts/drug effects; Fluorescent Antibody Technique; Heart/drug effects; Immunoprecipitation; Inflammasomes/metabolism; Mice; Mice, Inbred C57BL; Myocardium/metabolism; Myocytes, Cardiac/drug effects; Myocytes, Cardiac/metabolism; Myocytes, Cardiac/pathology; Organometallic Compounds/metabolism; Sepsis/metabolism

Key words

Carbon monoxide; Cardiac fibroblastcardiomyocyte interaction; Myocardial dysfunction; NLRP3 inflammasome; Sepsis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Organometallic Compounds / Sepsis / Inflammasomes / Fibroblasts / NLR Family, Pyrin Domain-Containing 3 Protein Limits: Animals Language: En Journal: Basic Res Cardiol Year: 2017 Type: Article

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