The influence of CYP3A5*3 and BCRPC421A genetic polymorphisms on the pharmacokinetics of felodipine in healthy Chinese volunteers.

Xiang, Q; Li, C; Zhao, X; Cui, Y M

Xiang, Q; Li, C; Zhao, X; Cui, Y M.

Affiliation

Xiang Q; Department of Pharmacy, Base for Clinical Trial, Peking University First Hospital, Beijing, China.
Li C; Department of Pharmacy, Base for Clinical Trial, Peking University First Hospital, Beijing, China.
Zhao X; Department of Pharmacy, Base for Clinical Trial, Peking University First Hospital, Beijing, China.
Cui YM; Department of Pharmacy, Base for Clinical Trial, Peking University First Hospital, Beijing, China.

J Clin Pharm Ther ; 42(3): 345-349, 2017 Jun.

Article in En | MEDLINE | ID: mdl-28244604

Subject(s)

ATP Binding Cassette Transporter, Subfamily G, Member 2/genetics; Calcium Channel Blockers/pharmacokinetics; Cytochrome P-450 CYP3A/genetics; Felodipine/pharmacokinetics; Neoplasm Proteins/genetics; Administration, Oral; Adult; Alleles; Area Under Curve; Asian People/genetics; Chromatography, Liquid; Genotype; Humans; Male; Pharmacogenetics; Polymorphism, Single Nucleotide; Prospective Studies; Tandem Mass Spectrometry

Key words

BCRPC421A; CYP3A5; Chinese; felodipine; pharmacokinetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Calcium Channel Blockers / Felodipine / Cytochrome P-450 CYP3A / ATP Binding Cassette Transporter, Subfamily G, Member 2 / Neoplasm Proteins Type of study: Observational_studies / Prognostic_studies Limits: Adult / Humans / Male Language: En Journal: J Clin Pharm Ther Journal subject: FARMACIA / TERAPEUTICA Year: 2017 Type: Article Affiliation country: China

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