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Development of a pharmacodynamic biomarker to measure target engagement from inhibition of the NGF-TrkA pathway.
Price, Eric A; Krasowska-Zoladek, Alicja; Nanda, Kausik K; Stachel, Shawn J; Henze, Darrell A.
Affiliation
  • Price EA; Departments of Neuroscience Pain and Department of Medicinal Chemistry, Merck Research Laboratories, Merck & Co., Inc, West Point, PA 19486, USA. Electronic address: eric_price2@merck.com.
  • Krasowska-Zoladek A; Departments of Neuroscience Pain and Department of Medicinal Chemistry, Merck Research Laboratories, Merck & Co., Inc, West Point, PA 19486, USA.
  • Nanda KK; Departments of Neuroscience Pain and Department of Medicinal Chemistry, Merck Research Laboratories, Merck & Co., Inc, West Point, PA 19486, USA.
  • Stachel SJ; Departments of Neuroscience Pain and Department of Medicinal Chemistry, Merck Research Laboratories, Merck & Co., Inc, West Point, PA 19486, USA.
  • Henze DA; Departments of Neuroscience Pain and Department of Medicinal Chemistry, Merck Research Laboratories, Merck & Co., Inc, West Point, PA 19486, USA.
J Neurosci Methods ; 282: 34-42, 2017 Apr 15.
Article in En | MEDLINE | ID: mdl-28279735
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Enzyme-Linked Immunosorbent Assay / Receptor, trkA / Nerve Growth Factor / Analgesics Type of study: Evaluation_studies / Prognostic_studies Limits: Animals / Female / Humans / Male / Middle aged Language: En Journal: J Neurosci Methods Year: 2017 Type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Enzyme-Linked Immunosorbent Assay / Receptor, trkA / Nerve Growth Factor / Analgesics Type of study: Evaluation_studies / Prognostic_studies Limits: Animals / Female / Humans / Male / Middle aged Language: En Journal: J Neurosci Methods Year: 2017 Type: Article