Super-Enhancer-Mediated RNA Processing Revealed by Integrative MicroRNA Network Analysis.

Suzuki, Hiroshi I; Young, Richard A; Sharp, Phillip A

Suzuki, Hiroshi I; Young, Richard A; Sharp, Phillip A.

Affiliation

Suzuki HI; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Young RA; Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Sharp PA; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: sharppa@mit.edu.

Cell ; 168(6): 1000-1014.e15, 2017 Mar 09.

Article in En | MEDLINE | ID: mdl-28283057

Subject(s)

Enhancer Elements, Genetic; MicroRNAs/metabolism; Animals; Azepines/pharmacology; Gene Expression Regulation; Histone Code; Humans; Mice; Neoplasms/genetics; Organ Specificity; RNA Processing, Post-Transcriptional/drug effects; Transcription Factors/metabolism; Transcription, Genetic; Triazoles/pharmacology

Key words

Brd4; DGCR8; Drosha; broad H3K4me3 domain; cancer; microRNA; super-enhancer

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Enhancer Elements, Genetic / MicroRNAs Type of study: Systematic_reviews Limits: Animals / Humans Language: En Journal: Cell Year: 2017 Type: Article Affiliation country: United States

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