An Acyl-Linked Dimer of Daptomycin Is Strongly Inhibited by the Bacterial Cell Wall.

Taylor, Robert M; Scott, Bradley; Taylor, Scott; Palmer, Michael

Taylor, Robert M; Scott, Bradley; Taylor, Scott; Palmer, Michael.

Affiliation

Taylor RM; Department of Chemistry, University of Waterloo , 200 University Avenue West, Waterloo, Ontario N2L 3G1, Canada.
Scott B; Department of Chemistry, University of Waterloo , 200 University Avenue West, Waterloo, Ontario N2L 3G1, Canada.
Taylor S; Department of Chemistry, University of Waterloo , 200 University Avenue West, Waterloo, Ontario N2L 3G1, Canada.
Palmer M; Department of Chemistry, University of Waterloo , 200 University Avenue West, Waterloo, Ontario N2L 3G1, Canada.

ACS Infect Dis ; 3(7): 462-466, 2017 07 14.

Article in En | MEDLINE | ID: mdl-28350438

Subject(s)

Anti-Bacterial Agents/pharmacology; Bacillus subtilis/drug effects; Cell Wall/drug effects; Daptomycin/pharmacology; Drug Resistance, Bacterial/physiology; Staphylococcus aureus/drug effects; Acylation; Anti-Bacterial Agents/chemical synthesis; Anti-Bacterial Agents/metabolism; Bacillus subtilis/growth & development; Bacillus subtilis/metabolism; Biological Transport; Cell Wall/chemistry; Cell Wall/metabolism; Daptomycin/chemical synthesis; Daptomycin/metabolism; Dicarboxylic Acids/chemistry; Dimerization; Liposomes/chemistry; Microbial Sensitivity Tests; Permeability; Staphylococcus aureus/growth & development; Staphylococcus aureus/metabolism; Stearic Acids/chemistry

Key words

antibiotic resistance; bacterial L-forms; cell wall permeability; lipopeptide antibiotics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Staphylococcus aureus / Bacillus subtilis / Cell Wall / Daptomycin / Drug Resistance, Bacterial / Anti-Bacterial Agents Language: En Journal: ACS Infect Dis Year: 2017 Type: Article Affiliation country: Canada

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