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Poly(GP) proteins are a useful pharmacodynamic marker for C9ORF72-associated amyotrophic lateral sclerosis.
Gendron, Tania F; Chew, Jeannie; Stankowski, Jeannette N; Hayes, Lindsey R; Zhang, Yong-Jie; Prudencio, Mercedes; Carlomagno, Yari; Daughrity, Lillian M; Jansen-West, Karen; Perkerson, Emilie A; O'Raw, Aliesha; Cook, Casey; Pregent, Luc; Belzil, Veronique; van Blitterswijk, Marka; Tabassian, Lilia J; Lee, Chris W; Yue, Mei; Tong, Jimei; Song, Yuping; Castanedes-Casey, Monica; Rousseau, Linda; Phillips, Virginia; Dickson, Dennis W; Rademakers, Rosa; Fryer, John D; Rush, Beth K; Pedraza, Otto; Caputo, Ana M; Desaro, Pamela; Palmucci, Carla; Robertson, Amelia; Heckman, Michael G; Diehl, Nancy N; Wiggs, Edythe; Tierney, Michael; Braun, Laura; Farren, Jennifer; Lacomis, David; Ladha, Shafeeq; Fournier, Christina N; McCluskey, Leo F; Elman, Lauren B; Toledo, Jon B; McBride, Jennifer D; Tiloca, Cinzia; Morelli, Claudia; Poletti, Barbara; Solca, Federica; Prelle, Alessandro.
Affiliation
  • Gendron TF; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
  • Chew J; Mayo Graduate School, Mayo Clinic, Jacksonville, FL 32224, USA.
  • Stankowski JN; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
  • Hayes LR; Mayo Graduate School, Mayo Clinic, Jacksonville, FL 32224, USA.
  • Zhang YJ; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
  • Prudencio M; Brain Science Institute and Department of Neurology, Johns Hopkins University, Baltimore, MD 21205, USA.
  • Carlomagno Y; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
  • Daughrity LM; Mayo Graduate School, Mayo Clinic, Jacksonville, FL 32224, USA.
  • Jansen-West K; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
  • Perkerson EA; Mayo Graduate School, Mayo Clinic, Jacksonville, FL 32224, USA.
  • O'Raw A; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
  • Cook C; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
  • Pregent L; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
  • Belzil V; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
  • van Blitterswijk M; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
  • Tabassian LJ; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
  • Lee CW; Mayo Graduate School, Mayo Clinic, Jacksonville, FL 32224, USA.
  • Yue M; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
  • Tong J; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
  • Song Y; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
  • Castanedes-Casey M; Mayo Graduate School, Mayo Clinic, Jacksonville, FL 32224, USA.
  • Rousseau L; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
  • Phillips V; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
  • Dickson DW; Mayo Graduate School, Mayo Clinic, Jacksonville, FL 32224, USA.
  • Rademakers R; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
  • Fryer JD; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
  • Rush BK; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
  • Pedraza O; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
  • Caputo AM; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
  • Desaro P; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
  • Palmucci C; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
  • Robertson A; Mayo Graduate School, Mayo Clinic, Jacksonville, FL 32224, USA.
  • Heckman MG; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
  • Diehl NN; Mayo Graduate School, Mayo Clinic, Jacksonville, FL 32224, USA.
  • Wiggs E; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
  • Tierney M; Mayo Graduate School, Mayo Clinic, Jacksonville, FL 32224, USA.
  • Braun L; Department of Psychiatry and Psychology, Mayo Clinic, Jacksonville, FL 32224, USA.
  • Farren J; Department of Psychiatry and Psychology, Mayo Clinic, Jacksonville, FL 32224, USA.
  • Lacomis D; Department of Neurology, Mayo Clinic, Jacksonville, FL 32224, USA.
  • Ladha S; Department of Neurology, Mayo Clinic, Jacksonville, FL 32224, USA.
  • Fournier CN; Department of Neurology, Mayo Clinic, Jacksonville, FL 32224, USA.
  • McCluskey LF; Department of Neurology, Mayo Clinic, Jacksonville, FL 32224, USA.
  • Elman LB; Section of Biostatistics, Mayo Clinic, Jacksonville, FL 32224, USA.
  • Toledo JB; Section of Biostatistics, Mayo Clinic, Jacksonville, FL 32224, USA.
  • McBride JD; Motor Neuron Disorders Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
  • Tiloca C; Motor Neuron Disorders Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
  • Morelli C; Motor Neuron Disorders Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
  • Poletti B; Motor Neuron Disorders Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
  • Solca F; Departments of Neurology and Pathology, University of Pittsburgh School of Medicine and the University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.
  • Prelle A; Departments of Neurology and Neurobiology, Barrow Neurological Institute, Phoenix, AZ 85013, USA.
Sci Transl Med ; 9(383)2017 03 29.
Article in En | MEDLINE | ID: mdl-28356511
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biomarkers / Dinucleotide Repeats / C9orf72 Protein / Amyotrophic Lateral Sclerosis Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Aged / Animals / Humans / Middle aged Language: En Journal: Sci Transl Med Journal subject: CIENCIA / MEDICINA Year: 2017 Type: Article Affiliation country: United States
Fulltext
Print
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biomarkers / Dinucleotide Repeats / C9orf72 Protein / Amyotrophic Lateral Sclerosis Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Aged / Animals / Humans / Middle aged Language: En Journal: Sci Transl Med Journal subject: CIENCIA / MEDICINA Year: 2017 Type: Article Affiliation country: United States