Uncoupling genotoxic stress responses from circadian control increases susceptibility to mammary carcinogenesis.

Fang, Mingzhu; Ohman Strickland, Pamela A; Kang, Hwan-Goo; Zarbl, Helmut

Fang, Mingzhu; Ohman Strickland, Pamela A; Kang, Hwan-Goo; Zarbl, Helmut.

Affiliation

Fang M; School of Public Health, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.
Ohman Strickland PA; Environmental and Occupational Health Sciences Institute, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.
Kang HG; NIEHS Center for Environmental Exposures and Disease, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.
Zarbl H; Cancer Institute of New Jersey, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.

Oncotarget ; 8(20): 32752-32768, 2017 May 16.

Article in En | MEDLINE | ID: mdl-28427145

Subject(s)

DNA Repair; Jet Lag Syndrome/complications; Mammary Neoplasms, Experimental/metabolism; Methylnitrosourea/toxicity; Period Circadian Proteins/metabolism; Animals; Cell Transformation, Neoplastic; Circadian Rhythm; DNA Repair/drug effects; Disease Models, Animal; Female; Jet Lag Syndrome/genetics; Jet Lag Syndrome/metabolism; Mammary Glands, Animal/metabolism; Mammary Neoplasms, Experimental/chemically induced; Mammary Neoplasms, Experimental/genetics; Rats; Rats, Inbred F344; Sirtuin 1/metabolism

Key words

DNA damage response and repair; Period 2; SIRT1; circadian rhythm; genetic susceptibility

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Jet Lag Syndrome / DNA Repair / Period Circadian Proteins / Mammary Neoplasms, Experimental / Methylnitrosourea Type of study: Prognostic_studies Limits: Animals Language: En Journal: Oncotarget Year: 2017 Type: Article Affiliation country: United States

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