Your browser doesn't support javascript.
loading
Endocrine network essential for reproductive success in Drosophila melanogaster.
Meiselman, Matthew; Lee, Sang Soo; Tran, Raymond-Tan; Dai, Hongjiu; Ding, Yike; Rivera-Perez, Crisalejandra; Wijesekera, Thilini P; Dauwalder, Brigitte; Noriega, Fernando Gabriel; Adams, Michael E.
Affiliation
  • Meiselman M; Department of Entomology, University of California, Riverside, CA 92521.
  • Lee SS; Department of Cell Biology & Neuroscience, University of California, Riverside, CA 92521.
  • Tran RT; Graduate Program in Cell, Molecular, and Developmental Biology, University of California, Riverside, CA 92521.
  • Dai H; Department of Entomology, University of California, Riverside, CA 92521.
  • Ding Y; Department of Cell Biology & Neuroscience, University of California, Riverside, CA 92521.
  • Rivera-Perez C; Graduate Program in Neuroscience, University of California, Riverside, CA 92521.
  • Wijesekera TP; Department of Entomology, University of California, Riverside, CA 92521.
  • Dauwalder B; Department of Cell Biology & Neuroscience, University of California, Riverside, CA 92521.
  • Noriega FG; Department of Entomology, University of California, Riverside, CA 92521.
  • Adams ME; Department of Cell Biology & Neuroscience, University of California, Riverside, CA 92521.
Proc Natl Acad Sci U S A ; 114(19): E3849-E3858, 2017 05 09.
Article in En | MEDLINE | ID: mdl-28439025
ABSTRACT
Ecdysis-triggering hormone (ETH) was originally discovered and characterized as a molt termination signal in insects through its regulation of the ecdysis sequence. Here we report that ETH persists in adult Drosophila melanogaster, where it functions as an obligatory allatotropin to promote juvenile hormone (JH) production and reproduction. ETH signaling deficits lead to sharply reduced JH levels and consequent reductions of ovary size, egg production, and yolk deposition in mature oocytes. Expression of ETH and ETH receptor genes is in turn dependent on ecdysone (20E). Furthermore, 20E receptor knockdown specifically in Inka cells reduces fecundity. Our findings indicate that the canonical developmental roles of 20E, ETH, and JH during juvenile stages are repurposed to function as an endocrine network essential for reproductive success.
Subject(s)
Key words
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Receptors, Peptide / Endocrine System / Insect Hormones Limits: Animals Language: En Journal: Proc Natl Acad Sci U S A Year: 2017 Type: Article
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Receptors, Peptide / Endocrine System / Insect Hormones Limits: Animals Language: En Journal: Proc Natl Acad Sci U S A Year: 2017 Type: Article