Targeting secondary protein complexes in drug discovery: studying the druggability and chemical biology of the HSP70/BAG1 complex.

Evans, Lindsay E; Jones, Keith; Cheeseman, Matthew D

Evans, Lindsay E; Jones, Keith; Cheeseman, Matthew D.

Affiliation

Evans LE; Cancer Research UK Cancer Therapeutics Unit at The Institute of Cancer Research, London SW7 3RP, UK. matthew.cheeseman@icr.ac.uk.
Jones K; Cancer Research UK Cancer Therapeutics Unit at The Institute of Cancer Research, London SW7 3RP, UK. matthew.cheeseman@icr.ac.uk.
Cheeseman MD; Cancer Research UK Cancer Therapeutics Unit at The Institute of Cancer Research, London SW7 3RP, UK. matthew.cheeseman@icr.ac.uk.

Chem Commun (Camb) ; 53(37): 5167-5170, 2017 May 04.

Article in En | MEDLINE | ID: mdl-28439591

Subject(s)

DNA-Binding Proteins/antagonists & inhibitors; Drug Discovery; Fluorescent Dyes/pharmacology; HSP70 Heat-Shock Proteins/antagonists & inhibitors; Small Molecule Libraries/pharmacology; Transcription Factors/antagonists & inhibitors; DNA-Binding Proteins/metabolism; Dose-Response Relationship, Drug; Fluorescence Polarization; Fluorescent Dyes/chemical synthesis; Fluorescent Dyes/chemistry; HSP70 Heat-Shock Proteins/metabolism; Humans; Models, Molecular; Molecular Structure; Small Molecule Libraries/chemical synthesis; Small Molecule Libraries/chemistry; Structure-Activity Relationship; Transcription Factors/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transcription Factors / HSP70 Heat-Shock Proteins / DNA-Binding Proteins / Small Molecule Libraries / Drug Discovery / Fluorescent Dyes Type of study: Prognostic_studies Limits: Humans Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2017 Type: Article Affiliation country: United kingdom

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