Alzheimer Disease/history; Amyloid/chemistry; Amyloidosis/history; Diabetes Mellitus, Type 2/history; Parkinson Disease/history; Proteostasis Deficiencies/history; Alzheimer Disease/drug therapy; Alzheimer Disease/metabolism; Alzheimer Disease/pathology; Amyloid/genetics; Amyloid/metabolism; Amyloidosis/drug therapy; Amyloidosis/metabolism; Amyloidosis/pathology; Diabetes Mellitus, Type 2/drug therapy; Diabetes Mellitus, Type 2/metabolism; Diabetes Mellitus, Type 2/pathology; Drugs, Investigational; Gene Expression Regulation; History, 21st Century; Humans; Immunoglobulin Light-chain Amyloidosis; Molecular Chaperones/genetics; Molecular Chaperones/metabolism; Molecular Targeted Therapy; Parkinson Disease/drug therapy; Parkinson Disease/metabolism; Parkinson Disease/pathology; Protein Aggregation, Pathological/history; Protein Aggregation, Pathological/metabolism; Protein Aggregation, Pathological/pathology; Protein Aggregation, Pathological/prevention & control; Protein Conformation; Protein Folding; Proteostasis Deficiencies/drug therapy; Proteostasis Deficiencies/metabolism; Proteostasis Deficiencies/pathology; Proteostasis Deficiencies/prevention & control

amyloidosis; chaperones; conformational diseases; functional amyloid; protein aggregation; protein homeostasis; quality control