Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation.

Ji, Yapeng; Yang, Chuanzhen; Tang, Zefang; Yang, Yongfeng; Tian, Yonglu; Yao, Hongwei; Zhu, Xi; Zhang, Zeming; Ji, Jiafu; Zheng, Xiaofeng

Ji, Yapeng; Yang, Chuanzhen; Tang, Zefang; Yang, Yongfeng; Tian, Yonglu; Yao, Hongwei; Zhu, Xi; Zhang, Zeming; Ji, Jiafu; Zheng, Xiaofeng.

Affiliation

Ji Y; State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing 100871, China.
Yang C; Department of Biochemistry and Molecular Biology, School of Life Sciences, Peking University, Beijing 100871, China.
Tang Z; State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing 100871, China.
Yang Y; Department of Biochemistry and Molecular Biology, School of Life Sciences, Peking University, Beijing 100871, China.
Tian Y; Biodynamic Optical Imaging Center, School of Life Sciences, Peking University, Beijing 100871, China.
Yao H; State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing 100871, China.
Zhu X; Department of Biochemistry and Molecular Biology, School of Life Sciences, Peking University, Beijing 100871, China.
Zhang Z; Department of Biochemistry and Molecular Biology, School of Life Sciences, Peking University, Beijing 100871, China.
Ji J; Department of Critical Care Medicine, The Third Hospital, Peking University, Beijing 100871, China.
Zheng X; Department of Critical Care Medicine, The Third Hospital, Peking University, Beijing 100871, China.

Nat Commun ; 8: 15308, 2017 05 18.

Article in En | MEDLINE | ID: mdl-28516914

Subject(s)

Colorectal Neoplasms/genetics; Gene Expression Regulation, Neoplastic; L-Lactate Dehydrogenase/genetics; Neoplastic Stem Cells/metabolism; Nuclear Proteins/genetics; Protein Processing, Post-Translational; Animals; Antineoplastic Agents/pharmacology; Carcinogenesis/genetics; Carcinogenesis/metabolism; Carcinogenesis/pathology; Colorectal Neoplasms/drug therapy; Colorectal Neoplasms/metabolism; Colorectal Neoplasms/pathology; DNA-Binding Proteins; Doxycycline/pharmacology; Drug Resistance, Neoplasm/genetics; Glycolysis/drug effects; Glycolysis/genetics; Humans; Isoenzymes/genetics; Isoenzymes/metabolism; L-Lactate Dehydrogenase/metabolism; Lactate Dehydrogenase 5; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplastic Stem Cells/drug effects; Neoplastic Stem Cells/pathology; Nuclear Proteins/antagonists & inhibitors; Nuclear Proteins/metabolism; Phenotype; Phosphorylation; Protein Binding; RNA, Small Interfering/genetics; RNA, Small Interfering/metabolism; Reactive Oxygen Species/metabolism; Tyrosine/metabolism; Xenograft Model Antitumor Assays

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neoplastic Stem Cells / Nuclear Proteins / Colorectal Neoplasms / Gene Expression Regulation, Neoplastic / Protein Processing, Post-Translational / L-Lactate Dehydrogenase Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2017 Type: Article Affiliation country: China

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