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CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells.
Kim, Jiyeon; Hu, Zeping; Cai, Ling; Li, Kailong; Choi, Eunhee; Faubert, Brandon; Bezwada, Divya; Rodriguez-Canales, Jaime; Villalobos, Pamela; Lin, Yu-Fen; Ni, Min; Huffman, Kenneth E; Girard, Luc; Byers, Lauren A; Unsal-Kacmaz, Keziban; Peña, Christopher G; Heymach, John V; Wauters, Els; Vansteenkiste, Johan; Castrillon, Diego H; Chen, Benjamin P C; Wistuba, Ignacio; Lambrechts, Diether; Xu, Jian; Minna, John D; DeBerardinis, Ralph J.
Affiliation
  • Kim J; Children's Medical Center Research Institute, UT Southwestern Medical Center, Dallas, Texas 75390, USA.
  • Hu Z; Children's Medical Center Research Institute, UT Southwestern Medical Center, Dallas, Texas 75390, USA.
  • Cai L; Children's Medical Center Research Institute, UT Southwestern Medical Center, Dallas, Texas 75390, USA.
  • Li K; Children's Medical Center Research Institute, UT Southwestern Medical Center, Dallas, Texas 75390, USA.
  • Choi E; Department of Pharmacology, UT Southwestern Medical Center, Dallas, Texas 75390, USA.
  • Faubert B; Children's Medical Center Research Institute, UT Southwestern Medical Center, Dallas, Texas 75390, USA.
  • Bezwada D; Children's Medical Center Research Institute, UT Southwestern Medical Center, Dallas, Texas 75390, USA.
  • Rodriguez-Canales J; Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, 2130 West Holcombe Boulevard, Houston, Texas 77030, USA.
  • Villalobos P; Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, 2130 West Holcombe Boulevard, Houston, Texas 77030, USA.
  • Lin YF; Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, Texas 75390, USA.
  • Ni M; Children's Medical Center Research Institute, UT Southwestern Medical Center, Dallas, Texas 75390, USA.
  • Huffman KE; Hamon Center for Therapeutic Oncology, UT Southwestern Medical Center, Dallas, Texas 75390, USA.
  • Girard L; Hamon Center for Therapeutic Oncology, UT Southwestern Medical Center, Dallas, Texas 75390, USA.
  • Byers LA; Department of Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, 2130 West Holcombe Boulevard, Houston, Texas 77030, USA.
  • Unsal-Kacmaz K; Oncology Research Unit, Pfizer, 401 North Middletown Road, Pearl River, New York 10965, USA.
  • Peña CG; Department of Pathology, UT Southwestern Medical Center, Dallas, Texas 75390, USA.
  • Heymach JV; Department of Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, 2130 West Holcombe Boulevard, Houston, Texas 77030, USA.
  • Wauters E; Respiratory Division, University of Gasthuisberg, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.
  • Vansteenkiste J; Respiratory Division, University of Gasthuisberg, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.
  • Castrillon DH; Department of Pathology, UT Southwestern Medical Center, Dallas, Texas 75390, USA.
  • Chen BPC; Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, Texas 75390, USA.
  • Wistuba I; Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, 2130 West Holcombe Boulevard, Houston, Texas 77030, USA.
  • Lambrechts D; Laboratory for Translational Genetics, Department of Human Genetics, KU Leuven, O&N 4 Herestraat 49 - box 912, 3000 Leuven, Belgium.
  • Xu J; VIB Center for Cancer Biology, KU Leuven, O&N 4 Herestraat 49 - box 912, 3000 Leuven, Belgium.
  • Minna JD; Children's Medical Center Research Institute, UT Southwestern Medical Center, Dallas, Texas 75390, USA.
  • DeBerardinis RJ; Hamon Center for Therapeutic Oncology, UT Southwestern Medical Center, Dallas, Texas 75390, USA.
Nature ; 546(7656): 168-172, 2017 06 01.
Article in En | MEDLINE | ID: mdl-28538732
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / DNA / Carbamoyl-Phosphate Synthase (Ammonia) / Proto-Oncogene Proteins p21(ras) / Protein Serine-Threonine Kinases / Lung Neoplasms Language: En Journal: Nature Year: 2017 Type: Article Affiliation country: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / DNA / Carbamoyl-Phosphate Synthase (Ammonia) / Proto-Oncogene Proteins p21(ras) / Protein Serine-Threonine Kinases / Lung Neoplasms Language: En Journal: Nature Year: 2017 Type: Article Affiliation country: United States