Associations between endothelin polymorphisms and aneurysmal subarachnoid hemorrhage, clinical vasospasm, delayed cerebral ischemia, and functional outcome.

Griessenauer, Christoph J; Starke, Robert M; Foreman, Paul M; Hendrix, Philipp; Harrigan, Mark R; Fisher, Winfield S; Vyas, Nilesh A; Lipsky, Robert H; Lin, Mingkuan; Walters, Beverly C; Pittet, Jean-Francois; Mathru, Mali

Griessenauer, Christoph J; Starke, Robert M; Foreman, Paul M; Hendrix, Philipp; Harrigan, Mark R; Fisher, Winfield S; Vyas, Nilesh A; Lipsky, Robert H; Lin, Mingkuan; Walters, Beverly C; Pittet, Jean-Francois; Mathru, Mali.

Affiliation

Griessenauer CJ; 1Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Starke RM; 2Department of Neurosurgery and Radiology, University of Miami, Florida.
Foreman PM; 3Department of Neurosurgery, University of Alabama at Birmingham, Alabama.
Hendrix P; 4Department of Neurosurgery, Saarland University Medical Center and Saarland University Faculty of Medicine, Homburg/Saar, Germany.
Harrigan MR; 3Department of Neurosurgery, University of Alabama at Birmingham, Alabama.
Fisher WS; 3Department of Neurosurgery, University of Alabama at Birmingham, Alabama.
Vyas NA; 5Department of Neurosciences, Inova Health System, Falls Church, Virginia.
Lipsky RH; 5Department of Neurosciences, Inova Health System, Falls Church, Virginia.
Lin M; 6Department of Molecular Neuroscience, George Mason University, Fairfax, Virginia; and.
Walters BC; 6Department of Molecular Neuroscience, George Mason University, Fairfax, Virginia; and.
Pittet JF; 3Department of Neurosurgery, University of Alabama at Birmingham, Alabama.
Mathru M; 5Department of Neurosciences, Inova Health System, Falls Church, Virginia.

J Neurosurg ; 128(5): 1311-1317, 2018 05.

Article in En | MEDLINE | ID: mdl-28548598

Subject(s)

Brain Ischemia/genetics; Endothelin-1/genetics; Intracranial Aneurysm/genetics; Receptor, Endothelin A/genetics; Subarachnoid Hemorrhage/genetics; Vasospasm, Intracranial/genetics; Brain Ischemia/therapy; Female; Follow-Up Studies; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Prospective Studies; Receptor, Endothelin B/genetics; Subarachnoid Hemorrhage/therapy; Treatment Outcome; Vasospasm, Intracranial/therapy

Key words

CARAS = Cerebral Aneurysm Renin Angiotensin System; CI = confidence interval; CONSCIOUS = Clazosentan to Overcome Neurological Ischemia and Infarct Occurring after Subarachnoid Hemorrhage; CTA = CT angiography; DCI = delayed cerebral ischemia; DSA = digital subtraction angiography; END1 = endothelin-1; ENDRA = endothelin receptor A; ENDRB = endothelin receptor B; ICU = intensive care unit; NO = nitric oxide; OR = odds ratio; SNP = single nucleotide polymorphism; TCD = transcranial Doppler ultrasonography; aSAH = aneurysmal subarachnoid hemorrhage; aneurysm; cerebral; delayed cerebral ischemia; endothelin; intracranial; mRS = modified Rankin scale; polymorphism; rupture; subarachnoid hemorrhage; vascular disorders; vasospasm

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Subarachnoid Hemorrhage / Intracranial Aneurysm / Brain Ischemia / Endothelin-1 / Vasospasm, Intracranial / Receptor, Endothelin A Type of study: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Female / Humans / Male / Middle aged Language: En Journal: J Neurosurg Year: 2018 Type: Article

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