Prediction of renal transporter-mediated drug-drug interactions for a drug which is an OAT substrate and inhibitor using PBPK modelling.

Ball, Kathryn; Jamier, Tanguy; Parmentier, Yannick; Denizot, Claire; Mallier, Agnes; Chenel, Marylore

Ball, Kathryn; Jamier, Tanguy; Parmentier, Yannick; Denizot, Claire; Mallier, Agnes; Chenel, Marylore.

Affiliation

Ball K; Clinical Pharmacokinetics and Pharmacometrics Department, Institut de Recherches Internationales Servier, Suresnes, France. Electronic address: kathryn.ball@servier.com.
Jamier T; Clinical Pharmacokinetics and Pharmacometrics Department, Institut de Recherches Internationales Servier, Suresnes, France.
Parmentier Y; Nonclinical Pharmacokinetics and Biopharmaceutical Research Department, Technologie Servier, Orleans, France.
Denizot C; Nonclinical Pharmacokinetics and Biopharmaceutical Research Department, Technologie Servier, Orleans, France.
Mallier A; Nonclinical Pharmacokinetics and Biopharmaceutical Research Department, Technologie Servier, Orleans, France.
Chenel M; Clinical Pharmacokinetics and Pharmacometrics Department, Institut de Recherches Internationales Servier, Suresnes, France.

Eur J Pharm Sci ; 106: 122-132, 2017 Aug 30.

Article in En | MEDLINE | ID: mdl-28552429

Subject(s)

Ciprofloxacin/metabolism; Kidney/metabolism; Organic Anion Transport Protein 1/antagonists & inhibitors; Organic Anion Transporters, Sodium-Independent/antagonists & inhibitors; Probenecid/metabolism; Tenofovir/metabolism; Animals; Area Under Curve; Cell Line; Ciprofloxacin/pharmacology; Drug Interactions; Humans; Inhibitory Concentration 50; Macaca fascicularis; Male; Models, Biological; Organic Anion Transport Protein 1/metabolism; Organic Anion Transporters, Sodium-Independent/metabolism; Permeability; Probenecid/pharmacology; Renal Reabsorption; Tenofovir/pharmacology

Key words

Drug-drug interaction; Kidney; Modelling; PBPK; Pharmacokinetics; Physiological model; Transporters

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ciprofloxacin / Probenecid / Organic Anion Transporters, Sodium-Independent / Organic Anion Transport Protein 1 / Tenofovir / Kidney Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Humans / Male Language: En Journal: Eur J Pharm Sci Journal subject: FARMACIA / FARMACOLOGIA / QUIMICA Year: 2017 Type: Article

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