Exposure-response relationship of ramucirumab in East Asian patients from RAINBOW: a randomized clinical trial in second-line treatment of gastric cancer.

Kim, Tae You; Yen, Chia-Jui; Al-Batran, Salah-Eddin; Ferry, David; Gao, Ling; Hsu, Yanzhi; Cheng, Rebecca; Orlando, Mauro; Ohtsu, Atsushi

Kim, Tae You; Yen, Chia-Jui; Al-Batran, Salah-Eddin; Ferry, David; Gao, Ling; Hsu, Yanzhi; Cheng, Rebecca; Orlando, Mauro; Ohtsu, Atsushi.

Affiliation

Kim TY; Seoul National University Cancer Hospital, Seoul, South Korea.
Yen CJ; Division of Hematology and Oncology, Department of Internal Medicine, Graduate Institute of Clinical Medicine, National Cheng Kung University Hospital, Tainan, Taiwan.
Al-Batran SE; Institute of Clinical Cancer Research (IKF), UCT-University Cancer Center, Frankfurt, Germany.
Ferry D; Eli Lilly and Company, Bridgewater, NJ, USA.
Gao L; Eli Lilly and Company, Bridgewater, NJ, USA.
Hsu Y; Eli Lilly and Company, Bridgewater, NJ, USA.
Cheng R; Eli Lilly and Company, Taipei, Taiwan.
Orlando M; Eli Lilly and Company, Buenos Aires, Argentina.
Ohtsu A; National Cancer Center, Hospital East, Kashiwa, Japan. aohtsu@east.ncc.go.jp.

Gastric Cancer ; 21(2): 276-284, 2018 Mar.

Article in En | MEDLINE | ID: mdl-28634748

Subject(s)

Adenocarcinoma/drug therapy; Antibodies, Monoclonal/pharmacokinetics; Antineoplastic Agents, Immunological/pharmacokinetics; Stomach Neoplasms/drug therapy; Adenocarcinoma/mortality; Adult; Aged; Antibodies, Monoclonal/therapeutic use; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Immunological/therapeutic use; Antineoplastic Combined Chemotherapy Protocols/therapeutic use; Asian People; Disease-Free Survival; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Paclitaxel/therapeutic use; Proportional Hazards Models; Stomach Neoplasms/mortality; Ramucirumab

Key words

East Asian patients; Exposure response; Gastric cancer; Ramucirumab; Vascular endothelial growth factor receptor-2

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stomach Neoplasms / Adenocarcinoma / Antineoplastic Agents, Immunological / Antibodies, Monoclonal Type of study: Clinical_trials / Prognostic_studies Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Gastric Cancer Journal subject: GASTROENTEROLOGIA / NEOPLASIAS Year: 2018 Type: Article Affiliation country: South Korea

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