MicroRNA-30e-5p promotes cell growth by targeting PTPN13 and indicates poor survival and recurrence in lung adenocarcinoma.

Zhuang, Li; Shou, Tao; Li, Ke; Gao, Chun-Lin; Duan, Lin-Can; Fang, Li-Zhou; Zhang, Qin-Yong; Chen, Zong-Ning; Zhang, Chao; Yang, Shou-Tao; Li, Gao-Feng

Zhuang, Li; Shou, Tao; Li, Ke; Gao, Chun-Lin; Duan, Lin-Can; Fang, Li-Zhou; Zhang, Qin-Yong; Chen, Zong-Ning; Zhang, Chao; Yang, Shou-Tao; Li, Gao-Feng.

Affiliation

Zhuang L; Department of Palliative Medicine, Palliative Medicine Research Center, The Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China.
Shou T; Department of Oncology, The First People's Hospital of Yunnan Province, Kunming, Yunnan Province, China.
Li K; The Second Department of Medicine, The Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China.
Gao CL; The Second Department of Medicine, The Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China.
Duan LC; Department of Thoracic Surgery, The Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China.
Fang LZ; The Second Department of Respiratory, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China.
Zhang QY; Department of Pharmacy, The Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China.
Chen ZN; Department of Cardiology, The People's Hospital of Lijiang City, Lijiang, Yunnan Province, China.
Zhang C; Cancer Treatment Center, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China.
Yang ST; Department of Nursing, The Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China.
Li GF; Department of Thoracic Surgery, The Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China.

J Cell Mol Med ; 21(11): 2852-2862, 2017 Nov.

Article in En | MEDLINE | ID: mdl-28653805

Subject(s)

Adenocarcinoma/genetics; Gene Expression Regulation, Neoplastic; Lung Neoplasms/genetics; MicroRNAs/genetics; Neoplasm Recurrence, Local/genetics; Protein Tyrosine Phosphatase, Non-Receptor Type 13/genetics; Adenocarcinoma/diagnosis; Adenocarcinoma/metabolism; Adenocarcinoma/mortality; Adenocarcinoma of Lung; Aged; Animals; Cell Line, Tumor; Cell Survival; ErbB Receptors/genetics; ErbB Receptors/metabolism; Female; Genes, Reporter; Genetic Vectors/chemistry; Genetic Vectors/metabolism; Humans; Lentivirus/genetics; Lentivirus/metabolism; Luciferases/genetics; Luciferases/metabolism; Lung Neoplasms/diagnosis; Lung Neoplasms/metabolism; Lung Neoplasms/mortality; Male; Mice, Nude; MicroRNAs/agonists; MicroRNAs/metabolism; Middle Aged; Neoplasm Recurrence, Local/diagnosis; Neoplasm Recurrence, Local/metabolism; Neoplasm Recurrence, Local/mortality; Oligoribonucleotides/genetics; Oligoribonucleotides/metabolism; Prognosis; Protein Tyrosine Phosphatase, Non-Receptor Type 13/metabolism; Signal Transduction; Survival Analysis; Xenograft Model Antitumor Assays

Key words

PTPN13; growth; lung adenocarcinoma; microRNA-30e-5p

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Adenocarcinoma / Gene Expression Regulation, Neoplastic / MicroRNAs / Protein Tyrosine Phosphatase, Non-Receptor Type 13 / Lung Neoplasms / Neoplasm Recurrence, Local Type of study: Diagnostic_studies / Prognostic_studies Language: En Journal: J Cell Mol Med Journal subject: BIOLOGIA MOLECULAR Year: 2017 Type: Article Affiliation country: China

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