The bradykinin-cGMP-PKG pathway augments insulin sensitivity via upregulation of MAPK phosphatase-5 and inhibition of JNK.

Frigolet, María E; Thomas, Garry; Beard, Kristin; Lu, Huogen; Liu, Lijiang; Fantus, I George

Frigolet, María E; Thomas, Garry; Beard, Kristin; Lu, Huogen; Liu, Lijiang; Fantus, I George.

Affiliation

Frigolet ME; Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada.
Thomas G; Banting and Best Diabetes Centre, Toronto, Ontario, Canada; and.
Beard K; Department of Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada.
Lu H; Banting and Best Diabetes Centre, Toronto, Ontario, Canada; and.
Liu L; Department of Physiology, University of Toronto, Toronto, Ontario, Canada.
Fantus IG; Department of Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada.

Am J Physiol Endocrinol Metab ; 313(3): E321-E334, 2017 09 01.

Article in En | MEDLINE | ID: mdl-28679626

Subject(s)

Adipocytes/drug effects; Bradykinin/pharmacology; Cyclic GMP-Dependent Protein Kinases/drug effects; Dual-Specificity Phosphatases/drug effects; Insulin Resistance; JNK Mitogen-Activated Protein Kinases/antagonists & inhibitors; Mitogen-Activated Protein Kinase Phosphatases/drug effects; RNA, Messenger/drug effects; Adipocytes/metabolism; Animals; Blotting, Western; Cyclic GMP/metabolism; Cyclic GMP-Dependent Protein Kinases/metabolism; Dual-Specificity Phosphatases/genetics; Dual-Specificity Phosphatases/metabolism; Glucose/metabolism; Guanylate Cyclase/drug effects; Guanylate Cyclase/metabolism; Immunoprecipitation; JNK Mitogen-Activated Protein Kinases/drug effects; Male; Mitogen-Activated Protein Kinase Phosphatases/metabolism; Nitric Oxide/metabolism; Nitric Oxide Synthase Type III/drug effects; Nitric Oxide Synthase Type III/metabolism; Phosphodiesterase Inhibitors/pharmacology; Proto-Oncogene Proteins c-akt/drug effects; Purinones/pharmacology; RNA, Messenger/metabolism; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Signal Transduction/drug effects

Key words

adipocytes; bradykinin; insulin resistance

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Insulin Resistance / RNA, Messenger / Bradykinin / Cyclic GMP-Dependent Protein Kinases / Adipocytes / JNK Mitogen-Activated Protein Kinases / Mitogen-Activated Protein Kinase Phosphatases / Dual-Specificity Phosphatases Type of study: Diagnostic_studies Limits: Animals Language: En Journal: Am J Physiol Endocrinol Metab Journal subject: ENDOCRINOLOGIA / FISIOLOGIA / METABOLISMO Year: 2017 Type: Article Affiliation country: Canada

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