Enhanced neuroprotection of anthocyanin-loaded PEG-gold nanoparticles against Aß<sub>1-42</sub>-induced neuroinflammation and neurodegeneration via the NF-<sub>K</sub>B /JNK/GSK3ß signaling pathway.

Kim, Min Ju; Rehman, Shafiq Ur; Amin, Faiz Ul; Kim, Myeong Ok

Enhanced neuroprotection of anthocyanin-loaded PEG-gold nanoparticles against Aß_1-42-induced neuroinflammation and neurodegeneration via the NF-_KB /JNK/GSK3ß signaling pathway.

Kim, Min Ju; Rehman, Shafiq Ur; Amin, Faiz Ul; Kim, Myeong Ok.

Affiliation

Kim MJ; Department of Biology and Applied Life Science (BK 21), College of Natural Sciences, Gyeongsang National University, Jinju, Republic of Korea.
Rehman SU; Department of Biology and Applied Life Science (BK 21), College of Natural Sciences, Gyeongsang National University, Jinju, Republic of Korea.
Amin FU; Department of Biology and Applied Life Science (BK 21), College of Natural Sciences, Gyeongsang National University, Jinju, Republic of Korea.
Kim MO; Department of Biology and Applied Life Science (BK 21), College of Natural Sciences, Gyeongsang National University, Jinju, Republic of Korea. Electronic address: mokim@gsnu.ac.kr.

Nanomedicine ; 13(8): 2533-2544, 2017 Nov.

Article in En | MEDLINE | ID: mdl-28736294

Subject(s)

Alzheimer Disease/drug therapy; Amyloid beta-Peptides/antagonists & inhibitors; Anthocyanins/therapeutic use; Gold/chemistry; Inflammation/drug therapy; Metal Nanoparticles/chemistry; Neuroprotective Agents/therapeutic use; Peptide Fragments/antagonists & inhibitors; Alzheimer Disease/immunology; Amyloid beta-Peptides/immunology; Animals; Anthocyanins/administration & dosage; Drug Delivery Systems; Glycogen Synthase Kinase 3 beta/immunology; Inflammation/immunology; MAP Kinase Signaling System/drug effects; Mice; NF-kappa B/immunology; Neuroprotective Agents/administration & dosage; Peptide Fragments/immunology; Polyethylene Glycols/chemistry; Signal Transduction/drug effects

Key words

Alzheimer's disease; Amyloid beta; Anthocyanins; Neurodegeneration; Neuroinflammation; PEG-AuNPs

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptide Fragments / Amyloid beta-Peptides / Neuroprotective Agents / Metal Nanoparticles / Alzheimer Disease / Gold / Inflammation / Anthocyanins Type of study: Prognostic_studies Limits: Animals Language: En Journal: Nanomedicine Journal subject: BIOTECNOLOGIA Year: 2017 Type: Article

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