Kindlin-2 Association with Rho GDP-Dissociation Inhibitor <i>&#945;</i> Suppresses Rac1 Activation and Podocyte Injury.

Sun, Ying; Guo, Chen; Ma, Ping; Lai, Yumei; Yang, Fan; Cai, Jun; Cheng, Zhehao; Zhang, Kuo; Liu, Zhongzhen; Tian, Yeteng; Sheng, Yue; Tian, Ruijun; Deng, Yi; Xiao, Guozhi; Wu, Chuanyue

Kindlin-2 Association with Rho GDP-Dissociation Inhibitor α Suppresses Rac1 Activation and Podocyte Injury.

Sun, Ying; Guo, Chen; Ma, Ping; Lai, Yumei; Yang, Fan; Cai, Jun; Cheng, Zhehao; Zhang, Kuo; Liu, Zhongzhen; Tian, Yeteng; Sheng, Yue; Tian, Ruijun; Deng, Yi; Xiao, Guozhi; Wu, Chuanyue.

Affiliation

Sun Y; Departments of Biology and suny@sustc.edu.cn xiaogz@sustc.edu.cn wucy@sustc.edu.cn.
Guo C; Shenzhen Key Laboratory of Cell Microenvironment, Southern University of Science and Technology, Shenzhen, China.
Ma P; Departments of Biology and.
Lai Y; Departments of Biology and.
Yang F; Department of Orthopedic Surgery, Rush University Medical Center, Chicago, Illinois; and.
Cai J; Departments of Biology and.
Cheng Z; Departments of Biology and.
Zhang K; Departments of Biology and.
Liu Z; Departments of Biology and.
Tian Y; Departments of Biology and.
Sheng Y; Departments of Biology and.
Tian R; Departments of Biology and.
Deng Y; Shenzhen Key Laboratory of Cell Microenvironment, Southern University of Science and Technology, Shenzhen, China.
Xiao G; Chemistry, and.
Wu C; Departments of Biology and.

J Am Soc Nephrol ; 28(12): 3545-3562, 2017 Dec.

Article in En | MEDLINE | ID: mdl-28775002

Subject(s)

Cytoskeletal Proteins/metabolism; Membrane Proteins/metabolism; Muscle Proteins/metabolism; Neoplasm Proteins/metabolism; Neuropeptides/metabolism; Podocytes/metabolism; rac1 GTP-Binding Protein/metabolism; rho Guanine Nucleotide Dissociation Inhibitor alpha/metabolism; Albuminuria/metabolism; Animals; Apoptosis; Cell Movement; Creatinine/analysis; Cytoskeletal Proteins/genetics; Disease Progression; Female; Fibrosis; Genotype; Humans; Kidney Glomerulus/pathology; Male; Membrane Proteins/genetics; Mice; Mice, Knockout; Muscle Proteins/genetics; Neoplasm Proteins/genetics; RNA, Small Interfering/metabolism; Renal Insufficiency/pathology; Signal Transduction

Key words

Kindlin-2; Rac1; RhoGDIα; Slit diaphragms; podocyte

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neuropeptides / Rac1 GTP-Binding Protein / Cytoskeletal Proteins / Podocytes / Rho Guanine Nucleotide Dissociation Inhibitor alpha / Membrane Proteins / Muscle Proteins / Neoplasm Proteins Type of study: Risk_factors_studies Limits: Animals / Female / Humans / Male Language: En Journal: J Am Soc Nephrol Journal subject: NEFROLOGIA Year: 2017 Type: Article

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