mGlu<sub>7</sub> potentiation rescues cognitive, social, and respiratory phenotypes in a mouse model of Rett syndrome.

Gogliotti, Rocco G; Senter, Rebecca K; Fisher, Nicole M; Adams, Jeffrey; Zamorano, Rocio; Walker, Adam G; Blobaum, Anna L; Engers, Darren W; Hopkins, Corey R; Daniels, J Scott; Jones, Carrie K; Lindsley, Craig W; Xiang, Zixiu; Conn, P Jeffrey; Niswender, Colleen M

mGlu₇ potentiation rescues cognitive, social, and respiratory phenotypes in a mouse model of Rett syndrome.

Gogliotti, Rocco G; Senter, Rebecca K; Fisher, Nicole M; Adams, Jeffrey; Zamorano, Rocio; Walker, Adam G; Blobaum, Anna L; Engers, Darren W; Hopkins, Corey R; Daniels, J Scott; Jones, Carrie K; Lindsley, Craig W; Xiang, Zixiu; Conn, P Jeffrey; Niswender, Colleen M.

Affiliation

Gogliotti RG; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.
Senter RK; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232, USA.
Fisher NM; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.
Adams J; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232, USA.
Zamorano R; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.
Walker AG; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232, USA.
Blobaum AL; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.
Engers DW; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232, USA.
Hopkins CR; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.
Daniels JS; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232, USA.
Jones CK; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.
Lindsley CW; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232, USA.
Xiang Z; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.
Conn PJ; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232, USA.
Niswender CM; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.

Sci Transl Med ; 9(403)2017 08 16.

Article in En | MEDLINE | ID: mdl-28814546

Subject(s)

Cognition; Receptors, Metabotropic Glutamate/metabolism; Respiration; Rett Syndrome/metabolism; Rett Syndrome/physiopathology; Social Behavior; Animals; Apnea/drug therapy; Apnea/physiopathology; Autopsy; CA1 Region, Hippocampal/drug effects; CA1 Region, Hippocampal/metabolism; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Humans; Long-Term Potentiation/drug effects; Male; Memory/drug effects; Methyl-CpG-Binding Protein 2/deficiency; Methyl-CpG-Binding Protein 2/metabolism; Mice; Motor Cortex/drug effects; Motor Cortex/metabolism; Motor Cortex/pathology; Neuronal Plasticity/drug effects; Phenotype; Picolinic Acids; RNA, Messenger/genetics; RNA, Messenger/metabolism; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate/genetics; Respiration/drug effects; Rett Syndrome/pathology; Transcription, Genetic/drug effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Respiration / Social Behavior / Rett Syndrome / Cognition / Receptors, Metabotropic Glutamate Limits: Animals / Female / Humans / Male Language: En Journal: Sci Transl Med Journal subject: CIENCIA / MEDICINA Year: 2017 Type: Article Affiliation country: United States

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