Estrogen receptor ß-dependent Notch1 activation protects vascular endothelium against tumor necrosis factor &#945; (TNF&#945;)-induced apoptosis.

Fortini, Francesca; Vieceli Dalla Sega, Francesco; Caliceti, Cristiana; Aquila, Giorgio; Pannella, Micaela; Pannuti, Antonio; Miele, Lucio; Ferrari, Roberto; Rizzo, Paola

Estrogen receptor ß-dependent Notch1 activation protects vascular endothelium against tumor necrosis factor α (TNFα)-induced apoptosis.

Fortini, Francesca; Vieceli Dalla Sega, Francesco; Caliceti, Cristiana; Aquila, Giorgio; Pannella, Micaela; Pannuti, Antonio; Miele, Lucio; Ferrari, Roberto; Rizzo, Paola.

Affiliation

Fortini F; From the Departments of Medical Sciences and.
Vieceli Dalla Sega F; From the Departments of Medical Sciences and.
Caliceti C; the Department of Chemistry "G. Ciamician" and Interdepartmental Centre for Industrial Research in Energy and Environment (CIRI EA), University of Bologna, 40126 Bologna, Italy.
Aquila G; the National Institute of Biostructures and Biosystems (INBB), 00136 Rome, Italy.
Pannella M; From the Departments of Medical Sciences and.
Pannuti A; the Interdepartmental Center for Industrial Research and Life Sciences (CIRI-SDV), Foundation IRET, University of Bologna, 40064 Ozzano Emilia (BO), Italy.
Miele L; the Stanley Scott Cancer Center, Louisiana State University Health Sciences Center and Louisiana Cancer Research Consortium, New Orleans, Louisiana 70112.
Ferrari R; the Stanley Scott Cancer Center, Louisiana State University Health Sciences Center and Louisiana Cancer Research Consortium, New Orleans, Louisiana 70112.
Rizzo P; From the Departments of Medical Sciences and.

J Biol Chem ; 292(44): 18178-18191, 2017 11 03.

Article in En | MEDLINE | ID: mdl-28893903

Subject(s)

Apoptosis; Endothelium, Vascular/metabolism; Estradiol/metabolism; Estrogen Receptor beta/agonists; Receptor, Notch1/agonists; Signal Transduction; Tumor Necrosis Factor-alpha/antagonists & inhibitors; Amyloid Precursor Protein Secretases/antagonists & inhibitors; Amyloid Precursor Protein Secretases/metabolism; Apoptosis/drug effects; Cells, Cultured; Endothelium, Vascular/cytology; Endothelium, Vascular/drug effects; Endothelium, Vascular/immunology; Estrogen Receptor alpha/agonists; Estrogen Receptor alpha/antagonists & inhibitors; Estrogen Receptor alpha/genetics; Estrogen Receptor alpha/metabolism; Estrogen Receptor beta/antagonists & inhibitors; Estrogen Receptor beta/genetics; Estrogen Receptor beta/metabolism; Human Umbilical Vein Endothelial Cells/cytology; Humans; Peptide Fragments/agonists; Peptide Fragments/chemistry; Peptide Fragments/genetics; Peptide Fragments/metabolism; Phosphorylation/drug effects; Protease Inhibitors/pharmacology; Protein Interaction Domains and Motifs; Protein Kinase Inhibitors/pharmacology; Protein Processing, Post-Translational/drug effects; Proto-Oncogene Proteins c-akt/agonists; Proto-Oncogene Proteins c-akt/metabolism; RNA Interference; Receptor, Notch1/chemistry; Receptor, Notch1/genetics; Receptor, Notch1/metabolism; Recombinant Proteins/chemistry; Recombinant Proteins/metabolism; Signal Transduction/drug effects; Tumor Necrosis Factor-alpha/metabolism

Key words

Akt; ERß; Notch pathway; Notch1; apoptosis; endothelial dysfunction; estrogen; estrogen receptor; tumor necrosis factor (TNF)

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Endothelium, Vascular / Signal Transduction / Tumor Necrosis Factor-alpha / Apoptosis / Estrogen Receptor beta / Estradiol / Receptor, Notch1 Language: En Journal: J Biol Chem Year: 2017 Type: Article

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