Ammonium trichloro [1,2-ethanediolato-O,O']-tellurate cures experimental visceral leishmaniasis by redox modulation of Leishmania donovani trypanothione reductase and inhibiting host integrin linked PI3K/Akt pathway.

Vishwakarma, Preeti; Parmar, Naveen; Chandrakar, Pragya; Sharma, Tanuj; Kathuria, Manoj; Agnihotri, Pramod K; Siddiqi, Mohammad Imran; Mitra, Kalyan; Kar, Susanta

Vishwakarma, Preeti; Parmar, Naveen; Chandrakar, Pragya; Sharma, Tanuj; Kathuria, Manoj; Agnihotri, Pramod K; Siddiqi, Mohammad Imran; Mitra, Kalyan; Kar, Susanta.

Affiliation

Vishwakarma P; Division of Parasitology, CSIR-Central Drug Research Institute, Jankipuram Extension, Sitapur Road, Lucknow, Uttar Pradesh, 226031, India.
Parmar N; Academy of Scientific and Innovative Research, Anusandhan Bhawan, New Delhi, India.
Chandrakar P; Division of Parasitology, CSIR-Central Drug Research Institute, Jankipuram Extension, Sitapur Road, Lucknow, Uttar Pradesh, 226031, India.
Sharma T; Academy of Scientific and Innovative Research, Anusandhan Bhawan, New Delhi, India.
Kathuria M; Division of Parasitology, CSIR-Central Drug Research Institute, Jankipuram Extension, Sitapur Road, Lucknow, Uttar Pradesh, 226031, India.
Agnihotri PK; Academy of Scientific and Innovative Research, Anusandhan Bhawan, New Delhi, India.
Siddiqi MI; Molecular and Structural Biology Division, CSIR-Central Drug Research Institute, Lucknow, India.
Mitra K; Electron Microscopy Unit, Sophisticated Analytical Instrument Facility, CSIR-Central Drug Research Institute, Lucknow, India.
Kar S; Division of Toxicology, CSIR-Central Drug Research Institute, Lucknow, India.

Cell Mol Life Sci ; 75(3): 563-588, 2018 02.

Article in En | MEDLINE | ID: mdl-28900667

Subject(s)

Ethylenes/therapeutic use; Integrins/antagonists & inhibitors; Leishmania donovani/enzymology; Leishmaniasis, Visceral/drug therapy; NADH, NADPH Oxidoreductases/drug effects; Animals; Cells, Cultured; Cricetinae; Disease Models, Animal; Ethylenes/pharmacology; Female; Host-Parasite Interactions/drug effects; Integrins/drug effects; Leishmania donovani/drug effects; Leishmania donovani/metabolism; Leishmaniasis, Visceral/metabolism; Leishmaniasis, Visceral/pathology; Male; Mice; Mice, Inbred BALB C; NADH, NADPH Oxidoreductases/metabolism; Oxidation-Reduction/drug effects; Phosphatidylinositol 3-Kinases/drug effects; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt/antagonists & inhibitors; Proto-Oncogene Proteins c-akt/drug effects; Signal Transduction/drug effects

Key words

AS101; Apoptosis; Immunomodulator; Integrin; Reactive oxygen species; Redox modulation; Visceral leishmaniasis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leishmania donovani / Integrins / Ethylenes / Leishmaniasis, Visceral / NADH, NADPH Oxidoreductases Type of study: Prognostic_studies Limits: Animals Language: En Journal: Cell Mol Life Sci Journal subject: BIOLOGIA MOLECULAR Year: 2018 Type: Article Affiliation country: India

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