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Evolving DNA methylation and gene expression markers of B-cell chronic lymphocytic leukemia are present in pre-diagnostic blood samples more than 10 years prior to diagnosis.
Georgiadis, Panagiotis; Liampa, Irene; Hebels, Dennie G; Krauskopf, Julian; Chatziioannou, Aristotelis; Valavanis, Ioannis; de Kok, Theo M C M; Kleinjans, Jos C S; Bergdahl, Ingvar A; Melin, Beatrice; Spaeth, Florentin; Palli, Domenico; Vermeulen, R C H; Vlaanderen, J; Chadeau-Hyam, Marc; Vineis, Paolo; Kyrtopoulos, Soterios A.
Affiliation
  • Georgiadis P; Institute of Biology, Medicinal Chemistry and Biotechnology, National Hellenic Research Foundation, 48, Vassileos Constantinou Avenue, 11635, Athens, Greece.
  • Liampa I; Institute of Biology, Medicinal Chemistry and Biotechnology, National Hellenic Research Foundation, 48, Vassileos Constantinou Avenue, 11635, Athens, Greece.
  • Hebels DG; Department of Toxicogenomics, Maastricht University, 6229, Maastricht, ER, Netherlands.
  • Krauskopf J; Department of Toxicogenomics, Maastricht University, 6229, Maastricht, ER, Netherlands.
  • Chatziioannou A; Institute of Biology, Medicinal Chemistry and Biotechnology, National Hellenic Research Foundation, 48, Vassileos Constantinou Avenue, 11635, Athens, Greece.
  • Valavanis I; Institute of Biology, Medicinal Chemistry and Biotechnology, National Hellenic Research Foundation, 48, Vassileos Constantinou Avenue, 11635, Athens, Greece.
  • de Kok TMCM; Department of Toxicogenomics, Maastricht University, 6229, Maastricht, ER, Netherlands.
  • Kleinjans JCS; Department of Toxicogenomics, Maastricht University, 6229, Maastricht, ER, Netherlands.
  • Bergdahl IA; Department of Biobank Research, and Occupational and Environmental Medicine, Department of Public Health and Clinical Medicine, Umeå University, 901 87, Umeå, Sweden.
  • Melin B; Department of Radiation Sciences, Oncology, Umeå University, 901 87, Umeå, Sweden.
  • Spaeth F; Department of Radiation Sciences, Oncology, Umeå University, 901 87, Umeå, Sweden.
  • Palli D; The Institute for Cancer Research and Prevention, 50141, Florence, Italy.
  • Vermeulen RCH; Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands.
  • Vlaanderen J; Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands.
  • Chadeau-Hyam M; Department of Epidemiology and Biostatistics, MRC-HPA Centre for Environment and Health, School of Public Health, Faculty of Medicine, Imperial College, London, W2 1PG, UK.
  • Vineis P; Department of Epidemiology and Biostatistics, MRC-HPA Centre for Environment and Health, School of Public Health, Faculty of Medicine, Imperial College, London, W2 1PG, UK.
  • Kyrtopoulos SA; Institute of Biology, Medicinal Chemistry and Biotechnology, National Hellenic Research Foundation, 48, Vassileos Constantinou Avenue, 11635, Athens, Greece. skyrt@eie.gr.
BMC Genomics ; 18(1): 728, 2017 Sep 13.
Article in En | MEDLINE | ID: mdl-28903739
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, Lymphocytic, Chronic, B-Cell / Biomarkers, Tumor / Gene Expression Profiling Type of study: Diagnostic_studies / Prognostic_studies Limits: Humans Language: En Journal: BMC Genomics Journal subject: GENETICA Year: 2017 Type: Article Affiliation country: Greece
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, Lymphocytic, Chronic, B-Cell / Biomarkers, Tumor / Gene Expression Profiling Type of study: Diagnostic_studies / Prognostic_studies Limits: Humans Language: En Journal: BMC Genomics Journal subject: GENETICA Year: 2017 Type: Article Affiliation country: Greece