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Targeting the MAPK Signaling Pathway in Cancer: Promising Preclinical Activity with the Novel Selective ERK1/2 Inhibitor BVD-523 (Ulixertinib).
Germann, Ursula A; Furey, Brinley F; Markland, William; Hoover, Russell R; Aronov, Alex M; Roix, Jeffrey J; Hale, Michael; Boucher, Diane M; Sorrell, David A; Martinez-Botella, Gabriel; Fitzgibbon, Matthew; Shapiro, Paul; Wick, Michael J; Samadani, Ramin; Meshaw, Kathryn; Groover, Anna; DeCrescenzo, Gary; Namchuk, Mark; Emery, Caroline M; Saha, Saurabh; Welsch, Dean J.
Affiliation
  • Germann UA; Vertex Pharmaceuticals Inc, Cambridge, Massachusetts.
  • Furey BF; Vertex Pharmaceuticals Inc, Cambridge, Massachusetts.
  • Markland W; Vertex Pharmaceuticals Inc, Cambridge, Massachusetts.
  • Hoover RR; Vertex Pharmaceuticals Inc, Cambridge, Massachusetts.
  • Aronov AM; Vertex Pharmaceuticals Inc, Cambridge, Massachusetts.
  • Roix JJ; BioMed Valley Discoveries, Inc., Kansas City, Missouri.
  • Hale M; Vertex Pharmaceuticals Inc, Cambridge, Massachusetts.
  • Boucher DM; Vertex Pharmaceuticals Inc, Cambridge, Massachusetts.
  • Sorrell DA; Horizon Discovery Ltd, Cambridge, United Kingdom.
  • Martinez-Botella G; Vertex Pharmaceuticals Inc, Cambridge, Massachusetts.
  • Fitzgibbon M; Vertex Pharmaceuticals Inc, Cambridge, Massachusetts.
  • Shapiro P; University of Maryland School of Pharmacy, Baltimore, Maryland.
  • Wick MJ; START, San Antonio, Texas.
  • Samadani R; University of Maryland School of Pharmacy, Baltimore, Maryland.
  • Meshaw K; Charles River Discovery Services, Morrisville, North Carolina.
  • Groover A; BioMed Valley Discoveries, Inc., Kansas City, Missouri.
  • DeCrescenzo G; BioMed Valley Discoveries, Inc., Kansas City, Missouri.
  • Namchuk M; Vertex Pharmaceuticals Inc, Cambridge, Massachusetts.
  • Emery CM; BioMed Valley Discoveries, Inc., Kansas City, Missouri.
  • Saha S; BioMed Valley Discoveries, Inc., Kansas City, Missouri.
  • Welsch DJ; BioMed Valley Discoveries, Inc., Kansas City, Missouri. dwelsch@biomed-valley.com.
Mol Cancer Ther ; 16(11): 2351-2363, 2017 11.
Article in En | MEDLINE | ID: mdl-28939558
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrroles / Proto-Oncogene Proteins B-raf / Protein Kinase Inhibitors / Aminopyridines / Melanoma Limits: Animals / Humans Language: En Journal: Mol Cancer Ther Journal subject: ANTINEOPLASICOS Year: 2017 Type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrroles / Proto-Oncogene Proteins B-raf / Protein Kinase Inhibitors / Aminopyridines / Melanoma Limits: Animals / Humans Language: En Journal: Mol Cancer Ther Journal subject: ANTINEOPLASICOS Year: 2017 Type: Article