Localization of the gene for X-linked nephrogenic diabetes insipidus to Xq28.

Kambouris, M; Dlouhy, S R; Trofatter, J A; Conneally, P M; Hodes, M E

Kambouris, M; Dlouhy, S R; Trofatter, J A; Conneally, P M; Hodes, M E.

Affiliation

Kambouris M; Department of Medical Genetics, Indiana University School of Medicine, Indianapolis 46223.

Am J Med Genet ; 29(1): 239-46, 1988 Jan.

Article in En | MEDLINE | ID: mdl-2894172

ABSTRACT

ABSTRACT

X-linked nephrogenic diabetes insipidus (NDI) was segregating in a large Indiana family. It was tested for linkage of the NDI gene to X-chromosome molecular markers. Maximum lod scores of 3.15 and 3.01 (theta = 0) obtained for the molecular markers F8A (F8C) and DXS15 (DX13) respectively, indicate that the NDI gene is located in Xq28. A lod score of 3.61 (theta = 0) was obtained with multipoint linkage analysis of F8A and DXS15.

Subject(s)

Diabetes Insipidus/genetics; Glycosuria, Renal/genetics; X Chromosome; Chromosome Mapping; Female; Genetic Markers; Humans; Lod Score; Male; Pedigree; Polymorphism, Restriction Fragment Length

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Collection: 01-internacional Database: MEDLINE Main subject: X Chromosome / Diabetes Insipidus / Glycosuria, Renal Limits: Female / Humans / Male Language: En Journal: Am J Med Genet Year: 1988 Type: Article

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