Aberrant promoter methylation of multiple genes in VSMC proliferation induced by Hcy.

Ma, Sheng-Chao; Cao, Jian-Cheng; Zhang, Hui-Ping; Jiao, Yun; Zhang, Hui; He, Yang-Yang; Wang, Yan-Hua; Yang, Xiao-Ling; Yang, An-Ning; Tian, Jue; Zhang, Ming-Hao; Yang, Xiao-Ming; Lu, Guan-Jun; Jin, Shao-Ju; Jia, Yue-Xia; Jiang, Yi-Deng

Ma, Sheng-Chao; Cao, Jian-Cheng; Zhang, Hui-Ping; Jiao, Yun; Zhang, Hui; He, Yang-Yang; Wang, Yan-Hua; Yang, Xiao-Ling; Yang, An-Ning; Tian, Jue; Zhang, Ming-Hao; Yang, Xiao-Ming; Lu, Guan-Jun; Jin, Shao-Ju; Jia, Yue-Xia; Jiang, Yi-Deng.

Affiliation

Ma SC; School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China.
Cao JC; School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China.
Zhang HP; Department of Prenatal Diagnosis Center, General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China.
Jiao Y; Department of Infectious Disease, General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China.
Zhang H; School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China.
He YY; School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China.
Wang YH; School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China.
Yang XL; School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China.
Yang AN; School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China.
Tian J; School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China.
Zhang MH; School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China.
Yang XM; School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China.
Lu GJ; Department of Urinary Surgery, General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China.
Jin SJ; School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China.
Jia YX; School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China.
Jiang YD; School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China.

Mol Med Rep ; 16(5): 7775-7783, 2017 Nov.

Article in En | MEDLINE | ID: mdl-28944836

Subject(s)

DNA Methylation/drug effects; Epigenesis, Genetic; Homocysteine/pharmacology; Myocytes, Smooth Muscle/drug effects; Promoter Regions, Genetic; Alu Elements; Atherosclerosis/genetics; Atherosclerosis/metabolism; Atherosclerosis/pathology; Cell Proliferation/drug effects; CpG Islands; Female; GTP Phosphohydrolases/genetics; GTP Phosphohydrolases/metabolism; Humans; Long Interspersed Nucleotide Elements; Mitochondrial Proteins/genetics; Mitochondrial Proteins/metabolism; Models, Biological; Muscle, Smooth, Vascular/cytology; Muscle, Smooth, Vascular/drug effects; Muscle, Smooth, Vascular/metabolism; Myocytes, Smooth Muscle/cytology; Myocytes, Smooth Muscle/metabolism; PTEN Phosphohydrolase/genetics; PTEN Phosphohydrolase/metabolism; Platelet-Derived Growth Factor/genetics; Platelet-Derived Growth Factor/metabolism; Primary Cell Culture; S-Adenosylhomocysteine/metabolism; S-Adenosylmethionine/metabolism; Tumor Suppressor Protein p53/genetics; Tumor Suppressor Protein p53/metabolism; Umbilical Veins/cytology; Umbilical Veins/drug effects; Umbilical Veins/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Promoter Regions, Genetic / DNA Methylation / Myocytes, Smooth Muscle / Epigenesis, Genetic / Homocysteine Type of study: Prognostic_studies / Risk_factors_studies Language: En Journal: Mol Med Rep Year: 2017 Type: Article

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