Matrix vesicles induce calcification of recipient vascular smooth muscle cells through multiple signaling pathways.

Chen, Neal X; O'Neill, Kalisha D; Moe, Sharon M

Chen, Neal X; O'Neill, Kalisha D; Moe, Sharon M.

Affiliation

Chen NX; Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
O'Neill KD; Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Moe SM; Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA; Roduebush Veterans Affairs Medical Center, Indianapolis, Indiana, USA. Electronic address: smoe@iu.edu.

Kidney Int ; 93(2): 343-354, 2018 02.

Article in En | MEDLINE | ID: mdl-29032812

Subject(s)

Calcium/metabolism; Endocytosis; Exosomes/metabolism; Extracellular Matrix/metabolism; Muscle, Smooth, Vascular/metabolism; Myocytes, Smooth Muscle/metabolism; Renal Insufficiency, Chronic/metabolism; Signal Transduction; Vascular Calcification/metabolism; Animals; Cells, Cultured; Coculture Techniques; Disease Models, Animal; Exosomes/ultrastructure; Extracellular Matrix/ultrastructure; Extracellular Signal-Regulated MAP Kinases/metabolism; MAP Kinase Kinase 1/metabolism; Muscle, Smooth, Vascular/ultrastructure; Myocytes, Smooth Muscle/ultrastructure; NADPH Oxidase 1/metabolism; Phenotype; Rats; Renal Insufficiency, Chronic/pathology; Superoxide Dismutase/metabolism; Vascular Calcification/pathology

Key words

calcium; chronic kidney disease; mineral metabolism; vascular calcification

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Calcium / Myocytes, Smooth Muscle / Endocytosis / Renal Insufficiency, Chronic / Extracellular Matrix / Exosomes / Vascular Calcification / Muscle, Smooth, Vascular Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals Language: En Journal: Kidney Int Year: 2018 Type: Article Affiliation country: United States

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