Emerging and evolving concepts in gene essentiality.
Nat Rev Genet
; 19(1): 34-49, 2018 Jan.
Article
in En
| MEDLINE
| ID: mdl-29033457
ABSTRACT
Gene essentiality is a founding concept of genetics with important implications in both fundamental and applied research. Multiple screens have been performed over the years in bacteria, yeasts, animals and more recently in human cells to identify essential genes. A mounting body of evidence suggests that gene essentiality, rather than being a static and binary property, is both context dependent and evolvable in all kingdoms of life. This concept of a non-absolute nature of gene essentiality changes our fundamental understanding of essential biological processes and could directly affect future treatment strategies for cancer and infectious diseases.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Genes, Essential
Limits:
Animals
/
Humans
Language:
En
Journal:
Nat Rev Genet
Journal subject:
GENETICA
Year:
2018
Type:
Article
Affiliation country:
Singapore