Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability.

Shen, Kuang; Choe, Abigail; Sabatini, David M

Shen, Kuang; Choe, Abigail; Sabatini, David M.

Affiliation

Shen K; Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Department of Biology, 9 Cambridge Center, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Koch Institute for Integrative Cancer Research, 77 Massachusetts Avenue, Cambridge, MA 02139, USA; Broad Institute of Harvard and Massachusetts Institute of Technology, 7 Cambridge Center, Cambridge, MA 02142, USA.
Choe A; Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Department of Biology, 9 Cambridge Center, Cambridge, MA 02142, USA.
Sabatini DM; Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Department of Biology, 9 Cambridge Center, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Koch Institute for Integrative Cancer Research, 77 Massachusetts Avenue, Cambridge, MA 02139, USA; Broad Institute of Harvard and Massachusetts Institute of Technology, 7 Cambridge Center, Cambridge, MA 02142, USA. Electron

Mol Cell ; 68(3): 552-565.e8, 2017 Nov 02.

Article in En | MEDLINE | ID: mdl-29056322

Subject(s)

Amino Acids/metabolism; Mechanistic Target of Rapamycin Complex 1/metabolism; Monomeric GTP-Binding Proteins/metabolism; Binding Sites; Enzyme Stability; Guanosine Triphosphate/metabolism; HEK293 Cells; Humans; Hydrolysis; Kinetics; Mechanistic Target of Rapamycin Complex 1/genetics; Models, Molecular; Monomeric GTP-Binding Proteins/chemistry; Monomeric GTP-Binding Proteins/genetics; Protein Binding; Protein Conformation; Protein Multimerization; Protein Subunits; Signal Transduction; Structure-Activity Relationship; Transfection

Key words

Rag GTPases; amino acid sensing; enzymatic mechanism; mTORC1; negative cooperativity

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Monomeric GTP-Binding Proteins / Mechanistic Target of Rapamycin Complex 1 / Amino Acids Limits: Humans Language: En Journal: Mol Cell Journal subject: BIOLOGIA MOLECULAR Year: 2017 Type: Article Affiliation country: United States

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